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BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin
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نویسنده
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zhu x.-j. ,liu y.d. ,dai z.-m. ,zhang x. ,yang x.q. ,li y. ,qiu m. ,fu j. ,hsu w. ,chen y.p. ,zhang z.
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منبع
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plos genetics - 2014 - دوره : 10 - شماره : 10
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چکیده
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Epidermal stratification of the mammalian skin requires proliferative basal progenitors to generate intermediate cells that separate from the basal layer and are replaced by post-mitotic cells. although wnt signaling has been implicated in this developmental process,the mechanism underlying wnt-mediated regulation of basal progenitors remains elusive. here we show that wnt secreted from proliferative basal cells is not required for their differentiation. however,epidermal production of wnts is essential for the formation of the spinous layer through modulation of a bmp-fgf signaling cascade in the dermis. the spinous layer defects caused by disruption of wnt secretion can be restored by transgenically expressed bmp4. non-cell autonomous bmp4 promotes activation of fgf7 and fgf10 signaling,leading to an increase in proliferative basal cell population. our findings identify an essential bmp-fgf signaling axis in the dermis that responds to the epidermal wnts and feedbacks to regulate basal progenitors during epidermal stratification. © 2014 zhu et al.
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آدرس
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institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China, department of biomedical genetics,center for oral biology,james p. wilmot cancer center,university of rochester medical center,rochester,ny, United States, department of biomedical genetics,center for oral biology,james p. wilmot cancer center,university of rochester medical center,rochester,ny, United States, department of cell and molecular biology,tulane university,new orleans,la, United States, institute of developmental and regenerative biology,college of life and environmental science,hangzhou normal university,zhejiang,china,key laboratory of mammalian organogenesis and regeneration,zhejiang, China
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Authors
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