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Arabidopsis BREVIPEDICELLUS Interacts with the SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA to Regulate KNAT2 and KNAT6 Expression in Control of Inflorescence Architecture
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نویسنده
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zhao m. ,yang s. ,chen c.-y. ,li c. ,shan w. ,lu w. ,cui y. ,liu x. ,wu k.
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منبع
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plos genetics - 2015 - دوره : 11 - شماره : 3
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چکیده
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Brevipedicellus (bp or knat1),a class-i knotted1-like homeobox (knox) transcription factor in arabidopsis thaliana,contributes to shaping the normal inflorescence architecture through negatively regulating other two class-i knox genes,knat2 and knat6. however,the molecular mechanism of bp-mediated transcription regulation remains unclear. in this study,we showed that bp directly interacts with the swi2/snf2 chromatin remodeling atpase brahma (brm) both in vitro and in vivo. loss-of-function brm mutants displayed inflorescence architecture defects,with clustered inflorescences,horizontally orientated pedicels,and short pedicels and internodes,a phenotype similar to the bp mutants. furthermore,the transcript levels of knat2 and knat6 were elevated in brm-3,bp-9 and brm-3 bp-9 double mutants. increased histone h3 lysine 4 tri-methylation (h3k4me3) levels were detected in brm-3,bp-9 and brm-3 bp-9 double mutants. moreover,brm and bp co-target to knat2 and knat6 genes,and bp is required for the binding of brm to knat2 and knat6. taken together,our results indicate that bp interacts with the chromatin remodeling factor brm to regulate the expression of knat2 and knat6 in control of inflorescence architecture. © 2015 zhao et al.
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آدرس
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key laboratory of south china agricultural plant molecular analysis and genetic improvement,south china botanical garden,chinese academy of sciences,guangzhou,china,university of chinese academy of sciences,beijing, China, key laboratory of south china agricultural plant molecular analysis and genetic improvement,south china botanical garden,chinese academy of sciences,guangzhou, China, institute of plant biology,national taiwan university,taipei, Taiwan, southern crop protection and food research centre,agriculture and agri-food canadaon,canada,department of biology,western university,london,on, Canada, state key laboratory for conservation and utilization of subtropical agro-bioresources/ guangdong key laboratory for postharvest science,college of horticultural science,south china agricultural university,guangzhou, China, state key laboratory for conservation and utilization of subtropical agro-bioresources/ guangdong key laboratory for postharvest science,college of horticultural science,south china agricultural university,guangzhou, China, southern crop protection and food research centre,agriculture and agri-food canadaon,canada,department of biology,western university,london,on, Canada, key laboratory of south china agricultural plant molecular analysis and genetic improvement,south china botanical garden,chinese academy of sciences,guangzhou, China, institute of plant biology,national taiwan university,taipei, Taiwan
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Authors
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