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Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons
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نویسنده
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lin t. ,pan p.-y. ,lai y.-t. ,chiang k.-w. ,hsieh h.-l. ,wu y.-p. ,ke j.-m. ,lee m.-c. ,liao s.-s. ,shih h.-t. ,tang c.-y. ,yang s.-b. ,cheng h.-c. ,wu j.-t. ,jan y.-n. ,lee h.-h.
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منبع
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plos genetics - 2015 - دوره : 11 - شماره : 11
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چکیده
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During development,certain drosophila sensory neurons undergo dendrite pruning that selectively eliminates their dendrites but leaves the axons intact. how these neurons regulate pruning activity in the dendrites remains unknown. here,we identify a coiled-coil protein spindle-f (spn-f) that is required for dendrite pruning in drosophila sensory neurons. spn-f acts downstream of ikk-related kinase ik2 in the same pathway for dendrite pruning. spn-f exhibits a punctate pattern in larval neurons,whereas these spn-f puncta become redistributed in pupal neurons,a step that is essential for dendrite pruning. the redistribution of spn-f from puncta in pupal neurons requires the phosphorylation of spn-f by ik2 kinase to decrease spn-f self-association,and depends on the function of microtubule motor dynein complex. spn-f is a key component to link ik2 kinase to dynein motor complex,and the formation of ik2/spn-f/dynein complex is critical for spn-f redistribution and for dendrite pruning. our findings reveal a novel regulatory mechanism for dendrite pruning achieved by temporal activation of ik2 kinase and dynein-mediated redistribution of ik2/spn-f complex in neurons. © 2015 lin et al.
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آدرس
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institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, institute of molecular biology,academia sinica,taipei, Taiwan, howard hughes medical institute,department of physiology,biochemistry and biophysics,university of california,san francisco,san francisco,ca, United States, department of life sciences,national chung hsing university,taichung, Taiwan, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan, howard hughes medical institute,department of physiology,biochemistry and biophysics,university of california,san francisco,san francisco,ca, United States, institute of molecular medicine,college of medicine,national taiwan university,taipei, Taiwan
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Authors
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