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Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus
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نویسنده
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zheng w. ,zhou j. ,he y. ,xie q. ,chen a. ,zheng h. ,shi l. ,zhao x. ,zhang c. ,huang q. ,fang k. ,lu g. ,ebbole d.j. ,li g. ,naqvi n.i. ,wang z.
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منبع
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plos genetics - 2015 - دوره : 11 - شماره : 12
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چکیده
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The retromer mediates protein trafficking through recycling cargo from endosomes to the trans-golgi network in eukaryotes. however,the role of such trafficking events during pathogen-host interaction remains unclear. here,we report that the cargo-recognition complex (movps35,movps26 and movps29) of the retromer is essential for appressorium-mediated host penetration by magnaporthe oryzae,the causal pathogen of the blast disease in rice. loss of retromer function blocked glycogen distribution and turnover of lipid bodies,delayed nuclear degeneration and reduced turgor during appressorial development. cytological observation revealed dynamic movps35-gfp foci co-localized with autophagy-related protein rfp-moatg8 at the periphery of autolysosomes. furthermore,rfp-moatg8 interacted with movps35-gfp in vivo,rfp-moatg8 was mislocalized to the vacuole and failed to recycle from the autolysosome in the absence of the retromer function,leading to impaired biogenesis of autophagosomes. we therefore conclude that retromer is essential for autophagy-dependent plant infection by the rice blast fungus. © 2015 zheng et al.
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آدرس
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fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, temasek life sciences laboratory and department of biological sciences,national university of singapore, Singapore, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China, department of plant pathology and microbiology,texas a&m university,college station,tx, United States, department of biochemistry and molecular biology,university of oklahoma health sciences center,oklahoma city,ok, United States, temasek life sciences laboratory and department of biological sciences,national university of singapore, Singapore, fujian-taiwan joint center for ecological control of crop pests,college of life science,fujian agriculture and forestry university,fuzhou,fujian,china,fujian university key laboratory for functional genomics of plant fungal pathogens,fujian agriculture and forestry university,fuzhou,fujian, China
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Authors
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