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RIC-7 promotes neuropeptide secretion
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نویسنده
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hao y. ,hu z. ,sieburth d. ,kaplan j.m.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 1
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چکیده
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Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles,synaptic vesicles (svs) and dense core vesicles (dcvs) respectively. relatively little is known about factors that differentially regulate sv and dcv secretion. here we identify a novel protein ric-7 that is required for neuropeptide secretion in caenorhabditis elegans. the ric-7 protein is expressed in all neurons and is localized to presynaptic terminals. imaging,electrophysiology,and behavioral analysis of ric-7 mutants indicates that acetylcholine release occurs normally,while neuropeptide release is significantly decreased. these results suggest that ric-7 promotes dcv-mediated secretion. © 2012 hao et al.
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آدرس
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department of molecular biology,massachusetts general hospital,boston,ma,united states,department of neurobiology,harvard medical school,boston,ma, United States, department of molecular biology,massachusetts general hospital,boston,ma,united states,department of neurobiology,harvard medical school,boston,ma, United States, zilkha neurogenetic institute,university of southern california,los angeles,ca, United States, department of molecular biology,massachusetts general hospital,boston,ma,united states,department of neurobiology,harvard medical school,boston,ma, United States
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Authors
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