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Development of a panel of genome-wide ancestry informative markers to study admixture throughout the americas
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نویسنده
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galanter j.m. ,fernandez-lopez j.c. ,gignoux c.r. ,barnholtz-sloan j. ,fernandez-rozadilla c. ,via m. ,hidalgo-miranda a. ,contreras a.v. ,figueroa l.u. ,raska p. ,jimenez-sanchez g. ,zolezzi i.s. ,torres m. ,ponte c.r. ,ruiz y. ,salas a. ,nguyen e. ,eng c. ,borjas l. ,zabala w. ,barreto g. ,gonzález f.r. ,ibarra a. ,taboada p. ,porras l. ,moreno f. ,bigham a. ,gutierrez g. ,brutsaert t. ,león-velarde f. ,moore l.g. ,vargas e. ,cruz m. ,escobedo j. ,rodriguez-santana j. ,rodriguez-cintrón w. ,chapela r. ,ford j.g. ,bustamante c. ,seminara d. ,shriver m. ,ziv e. ,burchard e.g. ,haile r. ,parra e. ,carracedo a.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 3
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چکیده
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Most individuals throughout the americas are admixed descendants of native american,european,and african ancestors. complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. we developed a panel of 446 ancestry informative markers (aims) optimized to estimate ancestral proportions in individuals and populations throughout latin america. we used genome-wide data from 953 individuals from diverse african,european,and native american populations to select aims optimized for each of the three main continental populations that form the basis of modern latin american populations. we selected markers on the basis of locus-specific branch length to be informative,well distributed throughout the genome,capable of being genotyped on widely available commercial platforms,and applicable throughout the americas by minimizing within-continent heterogeneity. we then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the aims panel to estimates based on genome-wide association study (gwas) data. the panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (r 2&0.9 for ancestral components with significant between-subject variance). finally,we genotyped samples from 18 populations from latin america using the aims panel and estimated variability in ancestry within and between these populations. this panel and its reference genotype information will be useful resources to explore population history of admixture in latin america and to correct for the potential effects of population stratification in admixed samples in the region.
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آدرس
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university of california san francisco,san francisco,ca, United States, instituto nacional de medicina genómica,mexico city, Mexico, university of california san francisco,san francisco,ca, United States, case western reserve university,cleveland,oh, United States, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela, Spain, universitat de barcelona,barcelona, Spain, instituto nacional de medicina genómica,mexico city, Mexico, instituto nacional de medicina genómica,mexico city, Mexico, instituto nacional de medicina genómica,mexico city, Mexico, case western reserve university,cleveland,oh, United States, instituto nacional de medicina genómica,mexico city, Mexico, instituto nacional de medicina genómica,mexico city, Mexico, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela, Spain, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela, Spain, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela, Spain, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela, Spain, university of california san francisco,san francisco,ca, United States, university of california san francisco,san francisco,ca, United States, universidad del zulia,maracaibo, Venezuela, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela,spain,universidad del zulia,maracaibo, Venezuela, universidad del valle,santiago de cali, Colombia, universidad industrial de santander,bucaramanga, Colombia, universidad de antioquia,medellín, Colombia, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela,spain,instituto de investigaciones forenses,sucre, Bolivia, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela,spain,universidad tecnológica de pereira,pereira, Colombia, unidad de genética forense,servicio médico-legal de chile,santiago de chile, Chile, university of michigan,ann arbor,mi, United States, university of colorado at boulder,boulder,co, United States, syracuse university,syracuse,ny, United States, universidad peruana cayetano heredia,lima, Peru, wake forest university,winston-salem,nc, United States, universidad mayor de san andrés,la paz, Bolivia, centro medico nacional siglo xxi,mexican social security institute (imss),mexico city, Mexico, hospital general regional 1,imss,mexico city, Mexico, centro de neumología pediátrica,san juan, Puerto Rico, va caribbean health system,san juan, Puerto Rico, instituto nacional de enfermedades respiratorias (iner),mexico city, Mexico, johns hopkins bloomberg school of public health,baltimore,md, United States, stanford university,stanford,ca, United States, national cancer institute,bethesda,md, United States, penn state university,university park,pa, United States, university of california san francisco,san francisco,ca, United States, university of california san francisco,san francisco,ca, United States, university of southern california,los angeles,ca, United States, university of toronto at mississauga,mississauga, Canada, fundación pública galega de medicina xenómica (sergas)-ciberer,universidade de santiago de compostela,santiago de compostela, Spain
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Authors
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