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Population structure of hispanics in the United States: the multi-Ethnic study of Atherosclerosis
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نویسنده
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manichaikul a. ,palmas w. ,rodriguez c.j. ,peralta c.a. ,divers j. ,guo x. ,chen w.-m. ,wong q. ,williams k. ,kerr k.f. ,taylor k.d. ,tsai m.y. ,goodarzi m.o. ,sale m.m. ,diez-roux a.v. ,rich s.s. ,rotter j.i. ,mychaleckyj j.c.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 4
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چکیده
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Using ~60,000 snps selected for minimal linkage disequilibrium,we perform population structure analysis of 1,374 unrelated hispanic individuals from the multi-ethnic study of atherosclerosis (mesa),with self-identification corresponding to central america (n = 93),cuba (n = 50),the dominican republic (n = 203),mexico (n = 708),puerto rico (n = 192),and south america (n = 111). by projection of principal components (pcs) of ancestry to samples from the hapmap phase iii and the human genome diversity panel (hgdp),we show the first two pcs quantify the caucasian,african,and native american origins,while the third and fourth pcs bring out an axis that aligns with known south-to-north geographic location of hgdp native american samples and further separates mesa mexican versus central/south american samples along the same axis. using k-means clustering computed from the first four pcs,we define four subgroups of the mesa hispanic cohort that show close agreement with self-identification,labeling the clusters as primarily dominican/cuban,mexican,central/south american,and puerto rican. to demonstrate our recommendations for genetic analysis in the mesa hispanic cohort,we present pooled and stratified association analysis of triglycerides for selected snps in the lpl and trib1 gene regions,previously reported in gwas of triglycerides in caucasians but as yet unconfirmed in hispanic populations. we report statistically significant evidence for genetic association in both genes,and we further demonstrate the importance of considering population substructure and genetic heterogeneity in genetic association studies performed in the united states hispanic population. © 2012 manichaikul et al.
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آدرس
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center for public health genomics,university of virginia,charlottesville,va,united states,department of public health sciences,division of biostatistics and epidemiology,university of virginia,charlottesville,va, United States, department of medicine,columbia university,new york,ny, United States, department of medicine and department of epidemiology,wake forest university school of medicine,winston-salem,nc, United States, department of medicine,division of nephrology,university of california san francisco,san francisco,ca,united states,division of general internal medicine,san francisco va medical center,san francisco,ca, United States, department of public health sciences,wake forest university school of medicine,winston-salem,nc, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, center for public health genomics,university of virginia,charlottesville,va,united states,department of public health sciences,division of biostatistics and epidemiology,university of virginia,charlottesville,va, United States, department of biostatistics,school of public health,university of washington,seattle,wa, United States, department of biostatistics,school of public health,university of washington,seattle,wa, United States, department of biostatistics,school of public health,university of washington,seattle,wa, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, department of laboratory medicine and pathology,university of minnesota,minneapolis,mn, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, center for public health genomics,university of virginia,charlottesville,va,united states,department of medicine and department of biochemistry and molecular genetics,university of virginia,charlottesville,va, United States, department of epidemiology,center for social epidemiology and population health,university of michigan,ann arbor,mi, United States, center for public health genomics,university of virginia,charlottesville,va, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, center for public health genomics,university of virginia,charlottesville,va, United States
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Authors
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