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A Sexual Ornament in Chickens Is Affected by Pleiotropic Alleles at HAO1 and BMP2,Selected during Domestication
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نویسنده
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johnsson m. ,gustafson i. ,rubin c.-j. ,sahlqvist a.-s. ,jonsson k.b. ,kerje s. ,ekwall o. ,kämpe o. ,andersson l. ,jensen p. ,wright d.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 8
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چکیده
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Domestication is one of the strongest forms of short-term,directional selection. although selection is typically only exerted on one or a few target traits,domestication can lead to numerous changes in many seemingly unrelated phenotypes. it is unknown whether such correlated responses are due to pleiotropy or linkage between separate genetic architectures. using three separate intercrosses between wild and domestic chickens,a locus affecting comb mass (a sexual ornament in the chicken) and several fitness traits (primarily medullary bone allocation and fecundity) was identified. this locus contains two tightly-linked genes,bmp2 and hao1,which together produce the range of pleiotropic effects seen. this study demonstrates the importance of pleiotropy (or extremely close linkage) in domestication. the nature of this pleiotropy also provides insights into how this sexual ornament could be maintained in wild populations. © 2012 johnsson et al.
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آدرس
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ifm biology,avian behavioural genomics and physiology group,linköping university,linköping, Sweden, ifm biology,avian behavioural genomics and physiology group,linköping university,linköping, Sweden, department of medical biochemistry and microbiology,bmc,uppsala university,uppsala, Sweden, department of medical sciences,the research group of autoimmunity,akademiska sjukhuset,uppsala university, Sweden, department of surgical sciences,orthopaedics,akademiska sjukhuset,uppsala university,uppsala, Sweden, department of medical sciences,the research group of autoimmunity,akademiska sjukhuset,uppsala university, Sweden, department of rheumatology and inflammation research,institute of medicine,the sahlgrenska academy,gothenburg, Sweden, department of medical sciences,the research group of autoimmunity,akademiska sjukhuset,uppsala university, Sweden, department of medical biochemistry and microbiology,bmc,uppsala university,uppsala, Sweden, ifm biology,avian behavioural genomics and physiology group,linköping university,linköping, Sweden, ifm biology,avian behavioural genomics and physiology group,linköping university,linköping, Sweden
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Authors
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