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Variation of BMP3 Contributes to Dog Breed Skull Diversity
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نویسنده
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schoenebeck j.j. ,hutchinson s.a. ,byers a. ,beale h.c. ,carrington b. ,faden d.l. ,rimbault m. ,decker b. ,kidd j.m. ,sood r. ,boyko a.r. ,fondon iii j.w. ,wayne r.k. ,bustamante c.d. ,ciruna b. ,ostrander e.a.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 8
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چکیده
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Since the beginnings of domestication,the craniofacial architecture of the domestic dog has morphed and radiated to human whims. by beginning to define the genetic underpinnings of breed skull shapes,we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. using intrabreed association mapping with museum specimen measurements,we show that skull shape is regulated by at least five quantitative trait loci (qtls). our detailed analysis using whole-genome sequencing uncovers a missense mutation in bmp3. validation studies in zebrafish show that bmp3 function in cranial development is ancient. our study reveals the causal variant for a canine qtl contributing to a major morphologic trait.
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آدرس
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cancer genetics branch,national human genome research institute,bethesda,md, United States, program in developmental and stem cell biology,the hospital for sick children,toronto,on, Canada, cancer genetics branch,national human genome research institute,bethesda,md, United States, cancer genetics branch,national human genome research institute,bethesda,md, United States, zebrafish core,national human genome research institute,bethesda,md, United States, cancer genetics branch,national human genome research institute,bethesda,md, United States, cancer genetics branch,national human genome research institute,bethesda,md, United States, cancer genetics branch,national human genome research institute,bethesda,md, United States, department of genetics,stanford school of medicine,stanford,ca, United States, zebrafish core,national human genome research institute,bethesda,md, United States, department of biomedical sciences,cornell university college of veterinary medicine,ithaca,ny, United States, department of biology,university of texas at arlington,arlington,tx, United States, department of ecology and evolutionary biology,university of california los angeles,los angeles,ca, United States, department of genetics,stanford school of medicine,stanford,ca, United States, program in developmental and stem cell biology,the hospital for sick children,toronto,on,canada,department of molecular genetics,university of toronto,toronto,on, Canada, cancer genetics branch,national human genome research institute,bethesda,md, United States
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Authors
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