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Determinants of Human Adipose Tissue Gene Expression: Impact of Diet,Sex,Metabolic Status,and Cis Genetic Regulation
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نویسنده
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viguerie n. ,montastier e. ,maoret j.-j. ,roussel b. ,combes m. ,valle c. ,villa-vialaneix n. ,iacovoni j.s. ,martinez j.a. ,holst c. ,astrup a. ,vidal h. ,clément k. ,hager j. ,saris w.h.m. ,langin d.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 9
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چکیده
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Weight control diets favorably affect parameters of the metabolic syndrome and delay the onset of diabetic complications. the adaptations occurring in adipose tissue (at) are likely to have a profound impact on the whole body response as at is a key target of dietary intervention. identification of environmental and individual factors controlling at adaptation is therefore essential. here,expression of 271 transcripts,selected for regulation according to obesity and weight changes,was determined in 515 individuals before,after 8-week low-calorie diet-induced weight loss,and after 26-week ad libitum weight maintenance diets. for 175 genes,opposite regulation was observed during calorie restriction and weight maintenance phases,independently of variations in body weight. metabolism and immunity genes showed inverse profiles. during the dietary intervention,network-based analyses revealed strong interconnection between expression of genes involved in de novo lipogenesis and components of the metabolic syndrome. sex had a marked influence on at expression of 88 transcripts,which persisted during the entire dietary intervention and after control for fat mass. in women,the influence of body mass index on expression of a subset of genes persisted during the dietary intervention. twenty-two genes revealed a metabolic syndrome signature common to men and women. genetic control of at gene expression by cis signals was observed for 46 genes. dietary intervention,sex,and cis genetic variants independently controlled at gene expression. these analyses help understanding the relative importance of environmental and individual factors that control the expression of human at genes and therefore may foster strategies aimed at improving at function in metabolic diseases. © 2012 viguerie et al.
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آدرس
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inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse, France, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse,france,nutrition and clinical biochemistry departments,toulouse university hospitals,toulouse, France, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse,france,get,genome and transcriptome platform,genotoul,toulouse, France, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse, France, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse, France, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse, France, samm,statistique,analyse,modélisation multidisciplinaire,university of paris 1,paris, France, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse,france,bioinformatic plateau,i2mc,institute of metabolic and cardiovascular diseases,toulouse, France, department of nutrition,food science,physiology,and toxicology,university of navarra,pamplona, Spain, institute of preventive medicine,copenhagen university hospitals,copenhagen, Denmark, department of human nutrition,faculty of life sciences,university of copenhagen,copenhagen, Denmark, inserm,u1060,inra,umr1235,lyon university,oullins, France, institute for cardiometabolism and nutrition (ican),pitié-salpêtrière hospital,paris,france,inserm,u872,nutriomics,cordelier research center,paris,france,university pierre et marie curie-paris 6,paris, France, cea-genomics institute,department of human genetics,national genotyping center,evry, France, department of human biology,nutrition and toxicology research institute (nutrim),maastricht university medical centre,maastricht, Netherlands, inserm,umr1048,obesity research laboratory,team 4,i2mc,institute of metabolic and cardiovascular diseases,toulouse,france,university of toulouse,umr1048,paul sabatier university,toulouse,france,nutrition and clinical biochemistry departments,toulouse university hospitals,toulouse, France
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Authors
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