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Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects
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نویسنده
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yang x. ,sun j. ,gao y. ,tan a. ,zhang h. ,hu y. ,feng j. ,qin x. ,tao s. ,chen z. ,kim s.-t. ,peng t. ,liao m. ,lin x. ,zhang z. ,tang m. ,li l. ,mo l. ,liang z. ,shi d. ,huang z. ,huang x. ,liu m. ,liu q. ,zhang s. ,trent j.m. ,zheng s.l. ,xu j. ,mo z.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 9
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چکیده
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Complement c3 and c4 play key roles in the main physiological activities of complement system,and their deficiencies or over-expression are associated with many clinical infectious or immunity diseases. a two-stage genome-wide association study (gwas) was performed for serum levels of c3 and c4. the first stage was conducted in 1,999 healthy chinese men,and the second stage was performed in an additional 1,496 subjects. we identified two snps,rs3753394 in cfh gene and rs3745567 in c3 gene,that are significantly associated with serum c3 levels at a genome-wide significance level (p = 7.33×10-11 and p = 1.83×10-9,respectively). for c4,one large genomic region on chromosome 6p21.3 is significantly associated with serum c4 levels. two snps (rs1052693 and rs11575839) were located in the mhc class i area that include hla-a,hla-c,and hla-b genes. two snps (rs2075799 and rs2857009) were located 5′ and 3′ of c4 gene. the other four snps,rs2071278,rs3763317,rs9276606,and rs241428,were located in the mhc class ii region that includes hla-dra,hla-drb,and hla-dqb genes. the combined p-values for those eight snps ranged from 3.19×10-22 to 5.62×10-97. hbsag-positive subjects have significantly lower c3 and c4 protein concentrations compared with hbsag-negative subjects (p<0.05). our study is the first gwas report which shows genetic components influence the levels of complement c3 and c4. our significant findings provide novel insights of their related autoimmune,infectious diseases,and molecular mechanisms. © 2012 yang et al.
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آدرس
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department of occupational health and environmental health,school of public health,guangxi medical university,nanning,guangxi,china,center for genomic and personalized medicine,guangxi medical university,nanning,guangxi, China, center for cancer genomics,wake forest university school of medicine,winston-salem,nc, United States, center for genomic and personalized medicine,guangxi medical university,nanning,guangxi,china,fudan-vari center for genetic epidemiology,school of life sciences,fudan university,shanghai, China, center for genomic and personalized medicine,guangxi medical university,nanning,guangxi, China, department of occupational health and environmental health,school of public health,guangxi medical university,nanning,guangxi,china,center for genomic and personalized medicine,guangxi medical university,nanning,guangxi, China, center for genomic and personalized medicine,guangxi medical university,nanning,guangxi,china,medical scientific research center,guangxi medical university,nanning,guangxi, China, center for cancer genomics,wake forest university school of medicine,winston-salem,nc, United States, department of clinical laboratory,the first affiliated hospital of guangxi medical university,nanning,guangxi, China, center for cancer genomics,wake forest university school of medicine,winston-salem,nc, United States, center for cancer genomics,wake forest university school of medicine,winston-salem,nc, United States, center for cancer genomics,wake forest university school of medicine,winston-salem,nc, United States, department of hepatobiliary surgery,the first affiliated hospital of guangxi medical university,nanning,guangxi,china,laboratory of genomic diversity,national cancer institute,national institutes of health,frederick,md, United States, center for genomic and personalized medicine,guangxi medical university,nanning,guangxi, China, fudan-vari center for genetic epidemiology,school of life sciences,fudan university,shanghai, China, department of microbiology,school of preclinical medicine,guangxi medical university,nanning,guangxi, China, college of life science and bioengineering,beijing university of technology,beijing, China, medical scientific research center,guangxi medical university,nanning,guangxi, China, institute of urology and nephrology,the first affiliated hospital of guangxi medical university,nanning,guangxi, China, medical examination center,fangchenggang first people's hospital,fangchenggang,guangxi, China, medical examination center,fangchenggang first people's hospital,fangchenggang,guangxi, China, medical examination center,fangchenggang first people's hospital,fangchenggang,guangxi, China, medical examination center,guigang people's hospital,guigang,guangxi, China, medical examination center,yulin first people's hospital,yulin,guangxi, China, institute of cardiovascular diseases,the first affiliated hospital of guangxi medical university,nanning,guangxi, China, center for genomic and personalized medicine,guangxi medical university,nanning,guangxi, China, center for genetic epidemiology,van andel research institute,grand rapids,mi, United States, center for cancer genomics,wake forest university school of medicine,winston-salem,nc, United States, center for cancer genomics,wake forest university school of medicine,winston-salem,nc,united states,fudan-vari center for genetic epidemiology,school of life sciences,fudan university,shanghai,china,center for genetic epidemiology,van andel research institute,grand rapids,mi,united states,fudan university institute of urology,huashan hospital,fudan university,shanghai, China, center for genomic and personalized medicine,guangxi medical university,nanning,guangxi,china,institute of urology and nephrology,the first affiliated hospital of guangxi medical university,nanning,guangxi, China
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Authors
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