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Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds
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نویسنده
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petersen j.l. ,mickelson j.r. ,rendahl a.k. ,valberg s.j. ,andersson l.s. ,axelsson j. ,bailey e. ,bannasch d. ,binns m.m. ,borges a.s. ,brama p. ,da câmara machado a. ,capomaccio s. ,cappelli k. ,cothran e.g. ,distl o. ,fox-clipsham l. ,graves k.t. ,guérin g. ,haase b. ,hasegawa t. ,hemmann k. ,hill e.w. ,leeb t. ,lindgren g. ,lohi h. ,lopes m.s. ,mcgivney b.a. ,mikko s. ,orr n. ,penedo m.c.t. ,piercy r.j. ,raekallio m. ,rieder s. ,røed k.h. ,swinburne j. ,tozaki t. ,vaudin m. ,wade c.m. ,mccue m.e.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 1
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چکیده
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Intense selective pressures applied over short evolutionary time have resulted in homogeneity within,but substantial variation among,horse breeds. utilizing this population structure,744 individuals from 33 breeds,and a 54,000 snp genotyping array,breed-specific targets of selection were identified using an fst-based statistic calculated in 500-kb windows across the genome. a 5.5-mb region of eca18,in which the myostatin (mstn) gene was centered,contained the highest signature of selection in both the paint and quarter horse. gene sequencing and histological analysis of gluteal muscle biopsies showed a promoter variant and intronic snp of mstn were each significantly associated with higher type 2b and lower type 1 muscle fiber proportions in the quarter horse,demonstrating a functional consequence of selection at this locus. signatures of selection on eca23 in all gaited breeds in the sample led to the identification of a shared,186-kb haplotype including two doublesex related mab transcription factor genes (dmrt2 and 3). the recent identification of a dmrt3 mutation within this haplotype,which appears necessary for the ability to perform alternative gaits,provides further evidence for selection at this locus. finally,putative loci for the determination of size were identified in the draft breeds and the miniature horse on eca11,as well as when signatures of selection surrounding candidate genes at other loci were examined. this work provides further evidence of the importance of mstn in racing breeds,provides strong evidence for selection upon gait and size,and illustrates the potential for population-based techniques to find genomic regions driving important phenotypes in the modern horse. © 2013 petersen et al.
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آدرس
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college of veterinary medicine,university of minnesota,st. paul,mn, United States, college of veterinary medicine,university of minnesota,st. paul,mn, United States, school of statistics,university of minnesota,minneapolis,mn, United States, college of veterinary medicine,university of minnesota,st. paul,mn, United States, department of animal breeding and genetics,swedish university of agricultural sciences,uppsala, Sweden, department of animal breeding and genetics,swedish university of agricultural sciences,uppsala, Sweden, department of veterinary science,university of kentucky,lexington,ky, United States, school of veterinary medicine,university of california davis,davis,ca, United States, equine analysis,midway,ky, United States, department of veterinary clinical science,university estadual paulista,botucatu, Brazil, school of veterinary medicine,university college dublin,dublin, Ireland, department of agriculture,university of the azores,angra do heroísmo, Portugal, faculty of veterinary medicine,university of perugia,perugia, Italy, faculty of veterinary medicine,university of perugia,perugia, Italy, college of veterinary medicine and biomedical science,texas aandm university,college station,tx, United States, institute for animal breeding and genetics,university of veterinary medicine hannover,hannover, Germany, animal health trust,lanwades park,newmarket,suffolk, United Kingdom, department of veterinary science,university of kentucky,lexington,ky, United States, animal genetics and integrative biology unit,french national institute for agricultural research,jouy en josas, France, faculty of veterinary science,university of sydney,new south wales, Australia, nihon bioresource college,koga,ibaraki, Japan, faculty of veterinary medicine,university of helsinki,helsinki, Finland, college of agriculture,food science and veterinary medicine,university college dublin,dublin, Ireland, institute of genetics,university of bern,bern, Switzerland, department of animal breeding and genetics,swedish university of agricultural sciences,uppsala, Sweden, faculty of veterinary medicine,university of helsinki,helsinki, Finland, department of agriculture,university of the azores,angra do heroísmo, Portugal, college of agriculture,food science and veterinary medicine,university college dublin,dublin, Ireland, department of animal breeding and genetics,swedish university of agricultural sciences,uppsala, Sweden, breakthrough breast cancer research centre,institute of cancer research,london, United Kingdom, school of veterinary medicine,university of california davis,davis,ca, United States, comparative neuromuscular diseases laboratory,royal veterinary college,london, United Kingdom, faculty of veterinary medicine,university of helsinki,helsinki, Finland, swiss national stud farm snstf,agroscope liebefeld-posieux research station,avenches, Switzerland, department of basic sciences and aquatic medicine,norwegian school of veterinary science,oslo, Norway, animal health trust,lanwades park,newmarket,suffolk,united kingdom,animal dna diagnostics,cambridge, United Kingdom, department of molecular genetics,laboratory of racing chemistry,utsunomiya,tochigi, Japan, animal health trust,lanwades park,newmarket,suffolk, United Kingdom, faculty of veterinary science,university of sydney,new south wales, Australia, college of veterinary medicine,university of minnesota,st. paul,mn, United States
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Authors
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