|
|
|
|
Genome-Wide Association Study Identifies a Novel Susceptibility Locus at 12q23.1 for Lung Squamous Cell Carcinoma in Han Chinese
|
|
|
|
|
|
|
|
نویسنده
|
dong j. ,jin g. ,wu c. ,guo h. ,zhou b. ,lv j. ,lu d. ,shi y. ,shu y. ,xu l. ,chu m. ,wang c. ,zhang r. ,dai j. ,jiang y. ,yu d. ,ma h. ,zhao x. ,yin z. ,yang l. ,li z. ,deng q. ,cao s. ,qin z. ,gong j. ,sun c. ,wang j. ,wu w. ,zhou g. ,chen h. ,guan p. ,chen y. ,liu x. ,liu l. ,xu p. ,han b. ,bai c. ,zhao y. ,zhang h. ,yan y. ,liu j. ,amos c.i. ,chen f. ,tan w. ,jin l. ,wu t. ,hu z. ,lin d. ,shen h.
|
|
منبع
|
plos genetics - 2013 - دوره : 9 - شماره : 1
|
|
چکیده
|
Adenocarcinoma (ac) and squamous cell carcinoma (sqcc) are two major histological subtypes of lung cancer. genome-wide association studies (gwas) have made considerable advances in the understanding of lung cancer susceptibility. obvious heterogeneity has been observed between different histological subtypes of lung cancer,but genetic determinants in specific to lung sqcc have not been systematically investigated. here,we performed the gwas analysis specifically for lung sqcc in 833 sqcc cases and 3,094 controls followed by a two-stage replication in additional 2,223 lung sqcc cases and 6,409 controls from chinese populations. we found that rs12296850 in slc17a8-nr1h4 gene region at12q23.1 was significantly associated with risk of lung sqcc at genome-wide significance level [additive model: odds ratio (or) = 0.78,95% confidence interval (ci) = 0.72-0.84,p = 1.19×10-10]. subjects carrying ag or gg genotype had a 26% (or = 0.74,95% ci = 0.67-0.81) or 32% (or = 0.68,95% ci = 0.56-0.83) decreased risk of lung sqcc,respectively,as compared with aa genotype. however,we did not observe significant association between rs12296850 and risk of lung ac in a total of 4,368 cases with lung ac and 9,486 controls (or = 0.96,95% ci = 0.90-1.02,p = 0.173). these results indicate that genetic variations on chromosome 12q23.1 may specifically contribute to lung sqcc susceptibility in chinese population. © 2013 dong et al.
|
|
|
|
|
آدرس
|
dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing,china,section of clinical epidemiology,jiangsu key laboratory of cancer biomarkers,prevention,and treatment,cancer center,nanjing medical university,nanjing,china,state key laboratory of reproductive medicine,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing,china,section of clinical epidemiology,jiangsu key laboratory of cancer biomarkers,prevention,and treatment,cancer center,nanjing medical university,nanjing, China, state key laboratory of molecular oncology and department of etiology and carcinogenesis,cancer institute and hospital,chinese academy of medical sciences and peking union medical college,beijing, China, inst. of occupational medicine and ministry of education key laboratory for environment and health,school of public health,tongji medical college,huazhong university of science and technology,wuhan, China, department of epidemiology,school of public health,china medical university,shenyang, China, the institute for chemical carcinogenesis,state key laboratory of respiratory disease,guangzhou medical college,guangzhou, China, state key laboratory of genetic engineering,center for fudan-vari genetic epidemiology and moe key laboratory of contemporary anthropology,school of life sciences,fudan university,shanghai, China, bio-x center and affiliated changning mental health center,ministry of edu. key laboratory for the genetics of developmental and neuropsychiatric disorders,shanghai jiaotong university,shanghai, China, department of thoracic surgery and oncology,first affiliated hospital of nanjing medical university,nanjing, China, department of thoracic surgery,affiliated cancer hospital of nanjing medical university,jiangsu cancer hospital,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, state key laboratory of molecular oncology and department of etiology and carcinogenesis,cancer institute and hospital,chinese academy of medical sciences and peking union medical college,beijing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, state key laboratory of genetic engineering,center for fudan-vari genetic epidemiology and moe key laboratory of contemporary anthropology,school of life sciences,fudan university,shanghai, China, department of epidemiology,school of public health,china medical university,shenyang, China, the institute for chemical carcinogenesis,state key laboratory of respiratory disease,guangzhou medical college,guangzhou, China, bio-x center and affiliated changning mental health center,ministry of edu. key laboratory for the genetics of developmental and neuropsychiatric disorders,shanghai jiaotong university,shanghai, China, inst. of occupational medicine and ministry of education key laboratory for environment and health,school of public health,tongji medical college,huazhong university of science and technology,wuhan, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, state key laboratory of genetic engineering,center for fudan-vari genetic epidemiology and moe key laboratory of contemporary anthropology,school of life sciences,fudan university,shanghai, China, department of epidemiology,school of public health,china medical university,shenyang, China, bio-x center and affiliated changning mental health center,ministry of edu. key laboratory for the genetics of developmental and neuropsychiatric disorders,shanghai jiaotong university,shanghai, China, state key laboratory of genetic engineering,center for fudan-vari genetic epidemiology and moe key laboratory of contemporary anthropology,school of life sciences,fudan university,shanghai, China, department of epidemiology,school of public health,china medical university,shenyang, China, department of thoracic surgery and oncology,first affiliated hospital of nanjing medical university,nanjing, China, department of thoracic surgery,cancer hospital,chinese academy of medical sciences and peking union medical college,beijing, China, cancer center of union hospital,tongji medical college,huazhong university of science and technology,wuhan, China, department of oncology,wuhan iron and steel group/corporation staff-worker hospital,wuhan, China, department of respiratory disease,shanghai chest hospital,shanghai jiaotong university,shanghai, China, department of respiratory disease,zhongshan hospital,fudan university,shanghai, China, department of radiation oncology,first affiliated hospital of china medical university,shenyang, China, department of radiotherapy,shenyang northern hospital,shenyang, China, department of radiotherapy,shenyang northern hospital,shenyang, China, department of surgery,nantong cancer hospital,nantong, China, department of genetics,university of texas m. d. anderson cancer center,houston,tx, United States, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing, China, state key laboratory of molecular oncology and department of etiology and carcinogenesis,cancer institute and hospital,chinese academy of medical sciences and peking union medical college,beijing, China, state key laboratory of genetic engineering,center for fudan-vari genetic epidemiology and moe key laboratory of contemporary anthropology,school of life sciences,fudan university,shanghai, China, inst. of occupational medicine and ministry of education key laboratory for environment and health,school of public health,tongji medical college,huazhong university of science and technology,wuhan, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing,china,section of clinical epidemiology,jiangsu key laboratory of cancer biomarkers,prevention,and treatment,cancer center,nanjing medical university,nanjing,china,state key laboratory of reproductive medicine,nanjing medical university,nanjing, China, state key laboratory of molecular oncology and department of etiology and carcinogenesis,cancer institute and hospital,chinese academy of medical sciences and peking union medical college,beijing, China, dept. of epidemiology and biostatistics and ministry of edu. (moe) key lab for modern toxicology,school of public health,nanjing medical university,nanjing,china,section of clinical epidemiology,jiangsu key laboratory of cancer biomarkers,prevention,and treatment,cancer center,nanjing medical university,nanjing,china,state key laboratory of reproductive medicine,nanjing medical university,nanjing, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|