Evidence of Gene-Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

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Evidence of Gene-Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors


نویسنده	nickels s. ,truong t. ,hein r. ,stevens k. ,buck k. ,behrens s. ,eilber u. ,schmidt m. ,häberle l. ,vrieling a. ,gaudet m. ,figueroa j. ,schoof n. ,spurdle a.b. ,rudolph a. ,fasching p.a. ,hopper j.l. ,makalic e. ,schmidt d.f. ,southey m.c. ,beckmann m.w. ,ekici a.b. ,fletcher o. ,gibson l. ,dos santos silva i. ,peto j. ,humphreys m.k. ,wang j. ,cordina-duverger e. ,menegaux f. ,nordestgaard b.g. ,bojesen s.e. ,lanng c. ,anton-culver h. ,ziogas a. ,bernstein l. ,clarke c.a. ,brenner h. ,müller h. ,arndt v. ,stegmaier c. ,brauch h. ,brüning t. ,harth v. ,mannermaa a. ,kataja v. ,kosma v.-m. ,hartikainen j.m. ,lambrechts d. ,smeets d. ,neven p. ,paridaens r. ,flesch-janys d. ,obi n. ,wang-gohrke s. ,couch f.j. ,olson j.e. ,vachon c.m. ,giles g.g. ,severi g. ,baglietto l. ,offit k. ,john e.m. ,miron a. ,andrulis i.l. ,knight j.a. ,glendon g. ,mulligan a.m. ,chanock s.j. ,lissowska j. ,liu j. ,cox a. ,cramp h. ,connley d. ,balasubramanian s. ,dunning a.m. ,shah m. ,trentham-dietz a. ,newcomb p. ,titus l. ,egan k. ,cahoon e.k. ,rajaraman p. ,sigurdson a.j. ,doody m.m. ,guénel p. ,pharoah p.d.p. ,schmidt m.k. ,hall p. ,easton d.f. ,garcia-closas m. ,milne r.l. ,chang-claude j. ,christina justenhoven h.b. ,ko y.-d. ,baisch c. ,fischer h.-p. ,hamann u. ,pesch b. ,rabstein s. ,lotz a. ,myöhänen e. ,kemiläinen h. ,thorne h. ,niedermayr e. ,bowtell d. ,chenevix-trench g. ,defazio a. ,gertig d. ,green a. ,webb p.
منبع	plos genetics - 2013 - دوره : 9 - شماره : 3
چکیده	Various common genetic susceptibility loci have been identified for breast cancer; however,it is unclear how they combine with lifestyle/environmental risk factors to influence risk. we undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. data from 24 studies of the breast cancer association consortium were pooled. using up to 34,793 invasive breast cancers and 41,099 controls,we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche,parity,breastfeeding,body mass index,height,oral contraceptive use,menopausal hormone therapy use,alcohol consumption,cigarette smoking,physical activity) in women of european ancestry. we used logistic regression models stratified by study and adjusted for age and performed likelihood ratio tests to assess gene-environment interactions. all statistical tests were two-sided. we replicated previously reported potential interactions between lsp1-rs3817198 and parity (pinteraction = 2.4×10-6) and between casp8-rs17468277 and alcohol consumption (pinteraction = 3.1×10-4). overall,the per-allele odds ratio (95% confidence interval) for lsp1-rs3817198 was 1.08 (1.01-1.16) in nulliparous women and ranged from 1.03 (0.96-1.10) in parous women with one birth to 1.26 (1.16-1.37) in women with at least four births. for casp8-rs17468277,the per-allele or was 0.91 (0.85-0.98) in those with an alcohol intake of <20 g/day and 1.45 (1.14-1.85) in those who drank ≥20 g/day. additionally,interaction was found between 1p11.2-rs11249433 and ever being parous (pinteraction = 5.3×10-5),with a per-allele or of 1.14 (1.11-1.17) in parous women and 0.98 (0.92-1.05) in nulliparous women. these data provide first strong evidence that the risk of breast cancer associated with some common genetic variants may vary with environmental risk factors.

آدرس	division of cancer epidemiology,german cancer research center (dkfz),heidelberg, Germany, inserm (national institute of health and medical research),cesp (center for research in epidemiology and population health),u1018,environmental epidemiology of cancer,villejuif, France, pmv research group at the department of child and adolescent psychiatry and psychotherapy,university of cologne,cologne, Germany, department of health sciences research,mayo clinic,rochester,mn, United States, department of preventive oncology,national center of tumor diseases,heidelberg, Germany, division of cancer epidemiology,german cancer research center (dkfz),heidelberg, Germany, division of cancer epidemiology,german cancer research center (dkfz),heidelberg, Germany, unit of environmental epidemiology,german cancer research center (dkfz),heidelberg, Germany, department of gynecology and obstetrics,university hospital,friedrich-alexander university erlangen-nuremberg,erlangen, Germany, division of cancer epidemiology,german cancer research center (dkfz),heidelberg,germany,department for health evidence,radboud university medical centre,nijmegen, Netherlands, epidemiology research program,division of cancer epidemiology,american cancer society,atlanta,ga, United States, division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, department of medical epidemiology and biostatistics,karolinska institutet,stockholm, Sweden, queensland institute of medical research,herston,qld, Australia, division of cancer epidemiology,german cancer research center (dkfz),heidelberg, Germany, department of gynecology and obstetrics,university hospital,friedrich-alexander university erlangen-nuremberg,erlangen,germany,department of medicine,david geffen school of medicine,university of california los angeles,los angeles,ca, United States, centre for molecular,environmental,genetic and analytic epidemiology,university of melbourne,melbourne, Australia, centre for molecular,environmental,genetic and analytic epidemiology,university of melbourne,melbourne, Australia, centre for molecular,environmental,genetic and analytic epidemiology,university of melbourne,melbourne, Australia, department of pathology,university of melbourne,melbourne, Australia, department of gynecology and obstetrics,university hospital,friedrich-alexander university erlangen-nuremberg,erlangen, Germany, institute of human genetics,friedrich alexander university erlangen-nuremberg,erlangen, Germany, breakthrough breast cancer research centre,institute of cancer research,london, United Kingdom, london school of hygiene and tropical medicine,london, United Kingdom, london school of hygiene and tropical medicine,london, United Kingdom, london school of hygiene and tropical medicine,london, United Kingdom, centre for cancer genetic epidemiology,department of public health and primary care,university of cambridge,cambridge, Germany, centre for cancer genetic epidemiology,department of public health and primary care,university of cambridge,cambridge, Germany, inserm (national institute of health and medical research),cesp (center for research in epidemiology and population health),u1018,environmental epidemiology of cancer,villejuif, France, inserm (national institute of health and medical research),cesp (center for research in epidemiology and population health),u1018,environmental epidemiology of cancer,villejuif, France, copenhagen general population study and department of clinical biochemistry,herlev university hospital,university of copenhagen,copenhagen, Denmark, copenhagen general population study and department of clinical biochemistry,herlev university hospital,university of copenhagen,copenhagen, Denmark, department of breast surgery,herlev university hospital,university of copenhagen,copenhagen, Denmark, department of epidemiology,university of california irvine,irvine,ca, United States, department of epidemiology,university of california irvine,irvine,ca, United States, beckman research institute of the city of hope,duarte,ca, United States, cancer prevention institute of california,fremont,ca,united states,division of epidemiology,department of health research and policy,stanford university school of medicine,stanford,ca, United States, division of clinical epidemiology and ageing research,german cancer research center (dkfz),heidelberg, Germany, division of clinical epidemiology and ageing research,german cancer research center (dkfz),heidelberg, Germany, division of clinical epidemiology and ageing research,german cancer research center (dkfz),heidelberg, Germany, saarland cancer registry,saarbrücken, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen, Germany, institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum, Germany, institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,institute for occupational medicine and maritime medicine,university medical center hamburg-eppendorf,hamburg, Germany, school of medicine,institute of clinical medicine,department of pathology and forensic medicine,university of eastern finland,kuopio,finland,biocenter kuopio,cancer center of eastern finland,university of eastern finland,kuopio, Finland, biocenter kuopio,cancer center of eastern finland,university of eastern finland,kuopio,finland,school of medicine,institute of clinical medicine,department of oncology,university of eastern finland,kuopio, Finland, school of medicine,institute of clinical medicine,department of pathology and forensic medicine,university of eastern finland,kuopio,finland,biocenter kuopio,cancer center of eastern finland,university of eastern finland,kuopio, Finland, school of medicine,institute of clinical medicine,department of pathology and forensic medicine,university of eastern finland,kuopio,finland,biocenter kuopio,cancer center of eastern finland,university of eastern finland,kuopio, Finland, vesalius research center (vrc),vib,leuven, Belgium, vesalius research center (vrc),vib,leuven, Belgium, multidisciplinary breast center,university hospital gasthuisberg,leuven, Belgium, multidisciplinary breast center,university hospital gasthuisberg,leuven, Belgium, dept. of cancer epidemiology/clinical cancer registry and inst. for med. biometrics and epidemiology,university clinic hamburg-eppendorf,hamburg, Germany, dept. of cancer epidemiology/clinical cancer registry and inst. for med. biometrics and epidemiology,university clinic hamburg-eppendorf,hamburg, Germany, department of obstetrics and gynecology,university of ulm,ulm, Germany, department of laboratory medicine and pathology,mayo clinic,rochester,mn, United States, department of health sciences research,mayo clinic,rochester,mn, United States, department of health sciences research,mayo clinic,rochester,mn, United States, cancer epidemiology centre,the cancer council victoria,melbourne,australia,centre for molecular,environmental,genetic,and analytic epidemiology,university of melbourne, Australia, cancer epidemiology centre,the cancer council victoria,melbourne,australia,centre for molecular,environmental,genetic,and analytic epidemiology,university of melbourne, Australia, cancer epidemiology centre,the cancer council victoria,melbourne,australia,centre for molecular,environmental,genetic,and analytic epidemiology,university of melbourne, Australia, memorial sloan-kettering cancer center,new york,ny, United States, cancer prevention institute of california,fremont,ca,united states,division of epidemiology,department of health research and policy,stanford university school of medicine,stanford,ca, United States, dana-farber cancer institute,boston,ma, United States, ontario cancer genetics network,fred a. litwin center for cancer genetics,samuel lunenfeld research institute,mount sinai hospital,toronto,canada,department of molecular genetics,university of toronto,toronto, Canada, samuel lunenfeld research institute,mount sinai hospital,toronto,canada,division of epidemiology,dalla lana school of public health,university of toronto,toronto, Canada, ontario cancer genetics network,samuel lunenfeld research institute,mount sinai hospital,toronto, Canada, laboratory medicine program,university health network,toronto,canada,department of laboratory medicine and pathobiology,university of toronto,toronto, Canada, division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, department of cancer epidemiology and prevention,m. sklodowska-curie memorial cancer center and institute of oncology,warsaw, Poland, human genetics,genome institute of singapore,singapore, Singapore, institute for cancer studies,department of oncology,university of sheffield,sheffield, United Kingdom, institute for cancer studies,department of oncology,university of sheffield,sheffield, United Kingdom, institute for cancer studies,department of oncology,university of sheffield,sheffield, United Kingdom, academic unit of surgical oncology,department of oncology,university of sheffield,sheffield, United Kingdom, department of oncology,university of cambridge,cambridge, United Kingdom, department of oncology,university of cambridge,cambridge, United Kingdom, university of wisconsin carbone cancer center,madison,wi, United States, university of wisconsin carbone cancer center,madison,wi,united states,fred hutchinson cancer research center,seattle,wa, United States, department of community and family medicine,department of pediatrics,dartmouth medical school,dartmouth-hitchcock medical center,lebanon,nh, United States, division of population sciences,moffitt cancer center and research institute,tampa,fl, United States, radiation epidemiology branch,division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, radiation epidemiology branch,division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, radiation epidemiology branch,division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, radiation epidemiology branch,division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, inserm (national institute of health and medical research),cesp (center for research in epidemiology and population health),u1018,environmental epidemiology of cancer,villejuif, France, department of oncology and department of public health and primary care,university of cambridge,cambridge, United Kingdom, division of molecular pathology and division of psychosocial research and epidemiology,netherlands cancer institute,amsterdam, Netherlands, division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, centre for cancer genetic epidemiology,department of public health and primary care,university of cambridge,cambridge, Germany, division of cancer epidemiology and genetics,national cancer institute,rockville,md,united states,sections of epidemiology and genetics,institute of cancer research and breakthrough breast cancer research centre,london, United Kingdom, genetic and molecular epidemiology group,human cancer genetics programme,spanish national cancer research centre (cnio),madrid, Spain, division of cancer epidemiology,german cancer research center (dkfz),heidelberg, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,university of tübingen, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,institute of pathology,university of bonn,bonn, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,molecular genetics of breast cancer,deutsches krebsforschungszentrum (dkfz),heidelberg, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,institute for prevention and occupational medicine of the german social accident insurance (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university faculty of medicine,homburg, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,institute for prevention and occupational medicine of the german social accident insurance (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university faculty of medicine,homburg, Germany, dr. margarete fischer-bosch-institute of clinical pharmacology,stuttgart,germany,university of tübingen,tübingen,germany,institute for prevention and occupational medicine of the german social accident insurance,institute of the ruhr-universität bochum (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university,faculty of medicine,homburg,germany,department of internal medicine,evangelische kliniken bonn ggmbh,johanniter krankenhaus,bonn,germany,institute of pathology,university of bonn,bonn,germany,molecular genetics of breast cancer,german cancer research center (dkfz),heidelberg,germany,institute for prevention and occupational medicine of the german social accident insurance (ipa),bochum,germany,institute and outpatient clinic of occupational medicine,saarland university medical center and saarland university faculty of medicine,homburg, Germany, the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, queensland institute of medical research,herston,qld,australia,the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, queensland institute of medical research,herston,qld,australia,the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, queensland institute of medical research,herston,qld,australia,the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, queensland institute of medical research,herston,qld,australia,the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, queensland institute of medical research,herston,qld,australia,the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia, queensland institute of medical research,herston,qld,australia,the kathleen cuningham foundation for resesarch into familial breast cancer (kconfab),peter maccallum cancer centre,east melbourne, Australia



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