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CRL2LRR-1 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Caenorhabditis elegans Germline
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نویسنده
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burger j. ,merlet j. ,tavernier n. ,richaudeau b. ,arnold a. ,ciosk r. ,bowerman b. ,pintard l.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 3
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چکیده
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The ubiquitin-proteolytic system controls the stability of proteins in space and time. in this study,using a temperature-sensitive mutant allele of the cul-2 gene,we show that crl2lrr-1 (cul-2 ring e3 ubiquitin-ligase and the leucine rich repeat 1 substrate recognition subunit) acts at multiple levels to control germline development. crl2lrr-1 promotes germ cell proliferation by counteracting the dna replication atl-1 checkpoint pathway. crl2lrr-1 also participates in the mitotic proliferation/meiotic entry decision,presumably controlling the stability of meiotic promoting factors in the mitotic zone of the germline. finally,crl2lrr-1 inhibits the first steps of meiotic prophase by targeting in mitotic germ cells degradation of the horma domain-containing protein htp-3,required for loading synaptonemal complex components onto meiotic chromosomes. given its widespread evolutionary conservation,cul-2 may similarly regulate germline development in other organisms as well. © 2013 burger et al.
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آدرس
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institut jacques monod,cnrs,umr 7592,université paris diderot,sorbonne paris cité,paris, France, institut jacques monod,cnrs,umr 7592,université paris diderot,sorbonne paris cité,paris, France, institut jacques monod,cnrs,umr 7592,université paris diderot,sorbonne paris cité,paris, France, institut jacques monod,cnrs,umr 7592,université paris diderot,sorbonne paris cité,paris, France, friedrich miescher institute for biomedical research,basel, Switzerland, friedrich miescher institute for biomedical research,basel, Switzerland, institute of molecular biology,university of oregon,eugene,or, United States, institut jacques monod,cnrs,umr 7592,université paris diderot,sorbonne paris cité,paris, France
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Authors
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