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Long Interspersed Element-1 (LINE-1): Passenger or Driver in Human Neoplasms?
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نویسنده
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rodić n. ,burns k.h.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 3
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چکیده
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Line-1 (l1) retrotransposons make up a significant portion of human genomes,with an estimated 500,000 copies per genome. like other retrotransposons,l1 retrotransposons propagate through rna sequences that are reverse transcribed into dna sequences,which are integrated into new genomic loci. l1 somatic insertions have the potential to disrupt the transcriptome by inserting into or nearby genes. by mutating genes and playing a role in epigenetic dysregulation,l1 transposons may contribute to tumorigenesis. studies of the mobilome have lagged behind other tumor characterizations at the sequence,transcript,and epigenetic levels. here,we consider evidence that l1 retrotransposons may sometimes drive human tumorigenesis. © 2013 rodić,burns.
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آدرس
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department of pathology,johns hopkins university school of medicine,baltimore,md, United States, department of pathology,johns hopkins university school of medicine,baltimore,md,united states,mckusick-nathans institute of genetic medicine,johns hopkins university school of medicine,baltimore,md,united states,sidney kimmel comprehensive cancer center,johns hopkins university school of medicine,baltimore,md,united states,high throughput biology center,johns hopkins university school of medicine,baltimore,md, United States
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Authors
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