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Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression
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نویسنده
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lin f.-j. ,shen l. ,jang c.-w. ,falnes p.ø. ,zhang y.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 5
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چکیده
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Mouse ikbkap gene encodes ikap-one of the core subunits of elongator-and is thought to be involved in transcription. however,the biological function of ikap,particularly within the context of an animal model,remains poorly characterized. we used a loss-of-function approach in mice to demonstrate that ikbkap is essential for meiosis during spermatogenesis. absence of ikbkap results in defects in synapsis and meiotic recombination,both of which result in increased apoptosis and complete arrest of gametogenesis. in ikbkap-mutant testes,a few meiotic genes are down-regulated,suggesting ikap's role in transcriptional regulation. in addition,ikbkap-mutant testes exhibit defects in wobble uridine trna modification,supporting a conserved trna modification function from yeast to mammals. thus,our study not only reveals a novel function of ikap in meiosis,but also suggests that ikap contributes to this process partly by exerting its effect on transcription and trna modification. © 2013 lin et al.
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آدرس
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howard hughes medical institute,harvard medical school,boston,ma,united states,program in cellular and molecular medicine,boston children's hospital,harvard medical school,boston,ma,united states,department of genetics,harvard medical school,boston,ma, United States, howard hughes medical institute,harvard medical school,boston,ma,united states,program in cellular and molecular medicine,boston children's hospital,harvard medical school,boston,ma,united states,department of genetics,harvard medical school,boston,ma, United States, howard hughes medical institute,harvard medical school,boston,ma,united states,department of genetics,university of north carolina at chapel hill,chapel hill,nc, United States, department of biosciences,university of oslo,oslo, Norway, howard hughes medical institute,harvard medical school,boston,ma,united states,program in cellular and molecular medicine,boston children's hospital,harvard medical school,boston,ma,united states,department of genetics,harvard medical school,boston,ma,united states,harvard stem cell institute,harvard medical school,boston,ma, United States
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Authors
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