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Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
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نویسنده
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corona e. ,chen r. ,sikora m. ,morgan a.a. ,patel c.j. ,ramesh a. ,bustamante c.d. ,butte a.j.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 5
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چکیده
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Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. we calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the human genome diversity panel. we found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward east asia. in addition,biliary liver cirrhosis,alopecia areata,bladder cancer,inflammatory bowel disease,membranous nephropathy,systemic lupus erythematosus,systemic sclerosis,ulcerative colitis,and vitiligo have undergone genetic risk differentiation. this analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. we anticipate that our findings will enable detailed analysis pertaining to the driving forces behind genetic risk differentiation. © 2013 corona et al.
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آدرس
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division of systems medicine,department of pediatrics,stanford university school of medicine,stanford,ca,united states,program in biomedical informatics,stanford university school of medicine,stanford,ca,united states,lucile packard children's hospital,palo alto,ca, United States, division of systems medicine,department of pediatrics,stanford university school of medicine,stanford,ca,united states,lucile packard children's hospital,palo alto,ca, United States, department of genetics,stanford university school of medicine,stanford,ca, United States, division of systems medicine,department of pediatrics,stanford university school of medicine,stanford,ca,united states,program in biomedical informatics,stanford university school of medicine,stanford,ca, United States, division of systems medicine,department of pediatrics,stanford university school of medicine,stanford,ca,united states,program in biomedical informatics,stanford university school of medicine,stanford,ca,united states,lucile packard children's hospital,palo alto,ca, United States, division of systems medicine,department of pediatrics,stanford university school of medicine,stanford,ca,united states,lucile packard children's hospital,palo alto,ca, United States, department of genetics,stanford university school of medicine,stanford,ca, United States, division of systems medicine,department of pediatrics,stanford university school of medicine,stanford,ca,united states,program in biomedical informatics,stanford university school of medicine,stanford,ca,united states,lucile packard children's hospital,palo alto,ca, United States
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Authors
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