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Distinct Translational Control in CD4+ T Cell Subsets
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نویسنده
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bjur e. ,larsson o. ,yurchenko e. ,zheng l. ,gandin v. ,topisirovic i. ,li s. ,wagner c.r. ,sonenberg n. ,piccirillo c.a.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 5
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چکیده
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Regulatory t cells expressing the transcription factor foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. genome-wide mrna expression studies have defined canonical signatures of t cell subsets. changes in steady-state mrna levels,however,often do not reflect those of corresponding proteins due to post-transcriptional mechanisms including mrna translation. here,we unveil a unique translational signature,contrasting cd4+foxp3+ regulatory t (tfoxp3+) and cd4+foxp3- non-regulatory t (tfoxp3-) cells,which imprints subset-specific protein expression. we further show that translation of eukaryotic translation initiation factor 4e (eif4e) is induced during t cell activation and,in turn,regulates translation of cell cycle related mrnas and proliferation in both tfoxp3- and tfoxp3+ cells. unexpectedly,eif4e also affects foxp3 expression and thereby lineage identity. thus,mrna-specific translational control directs both common and distinct cellular processes in cd4+ t cell subsets. © 2013 bjur et al.
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آدرس
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department of microbiology and immunology,mcgill university,montreal,canada,focis centre of excellence,research institute of the mcgill university health centre,montreal, Canada, department of biochemistry,goodman cancer research centre,mcgill university,montreal,canada,department of oncology-pathology,cancer center karolinska,karolinska institutet,stockholm, Sweden, department of microbiology and immunology,mcgill university,montreal,canada,focis centre of excellence,research institute of the mcgill university health centre,montreal, Canada, department of microbiology and immunology,mcgill university,montreal,canada,focis centre of excellence,research institute of the mcgill university health centre,montreal, Canada, department of biochemistry,goodman cancer research centre,mcgill university,montreal, Canada, department of biochemistry,goodman cancer research centre,mcgill university,montreal,canada,lady davis institute for medical research,sir mortimer b. davis-jewish general hospital and department of oncology,mcgill university,montreal, Canada, department of chemistry,university of minnesota,minneapolis,mn, United States, department of chemistry,university of minnesota,minneapolis,mn, United States, department of biochemistry,goodman cancer research centre,mcgill university,montreal, Canada, department of microbiology and immunology,mcgill university,montreal,canada,focis centre of excellence,research institute of the mcgill university health centre,montreal, Canada
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Authors
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