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Comparative Genomic and Functional Analysis of 100 Lactobacillus rhamnosus Strains and Their Comparison with Strain GG
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نویسنده
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douillard f.p. ,ribbera a. ,kant r. ,pietilä t.e. ,järvinen h.m. ,messing m. ,randazzo c.l. ,paulin l. ,laine p. ,ritari j. ,caggia c. ,lähteinen t. ,brouns s.j.j. ,satokari r. ,von ossowski i. ,reunanen j. ,palva a. ,de vos w.m.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 8
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چکیده
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Lactobacillus rhamnosus is a lactic acid bacterium that is found in a large variety of ecological habitats,including artisanal and industrial dairy products,the oral cavity,intestinal tract or vagina. to gain insights into the genetic complexity and ecological versatility of the species l. rhamnosus,we examined the genomes and phenotypes of 100 l. rhamnosus strains isolated from diverse sources. the genomes of 100 l. rhamnosus strains were mapped onto the l. rhamnosus gg reference genome. these strains were phenotypically characterized for a wide range of metabolic,antagonistic,signalling and functional properties. phylogenomic analysis showed multiple groupings of the species that could partly be associated with their ecological niches. we identified 17 highly variable regions that encode functions related to lifestyle,i.e. carbohydrate transport and metabolism,production of mucus-binding pili,bile salt resistance,prophages and crispr adaptive immunity. integration of the phenotypic and genomic data revealed that some l. rhamnosus strains possibly resided in multiple niches,illustrating the dynamics of bacterial habitats. the present study showed two distinctive geno-phenotypes in the l. rhamnosus species. the geno-phenotype a suggests an adaptation to stable nutrient-rich niches,i.e. milk-derivative products,reflected by the alteration or loss of biological functions associated with antimicrobial activity spectrum,stress resistance,adaptability and fitness to a distinctive range of habitats. in contrast,the geno-phenotype b displays adequate traits to a variable environment,such as the intestinal tract,in terms of nutrient resources,bacterial population density and host effects. © 2013 douillard et al.
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آدرس
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department of veterinary biosciences,university of helsinki,helsinki, Finland, department of veterinary biosciences,university of helsinki,helsinki,finland,laboratory of microbiology,wageningen university,wageningen, Netherlands, department of veterinary biosciences,university of helsinki,helsinki, Finland, department of veterinary biosciences,university of helsinki,helsinki, Finland, infection biology program,department of bacteriology and immunology,haartman institute,university of helsinki,helsinki, Finland, infection biology program,department of bacteriology and immunology,haartman institute,university of helsinki,helsinki, Finland, department of agri-food and environmental system management,university of catania,catania, Italy, institute of biotechnology,university of helsinki,helsinki, Finland, institute of biotechnology,university of helsinki,helsinki, Finland, department of veterinary biosciences,university of helsinki,helsinki, Finland, department of agri-food and environmental system management,university of catania,catania, Italy, department of veterinary biosciences,university of helsinki,helsinki, Finland, laboratory of microbiology,wageningen university,wageningen, Netherlands, department of veterinary biosciences,university of helsinki,helsinki,finland,functional foods forum,university of turku,turku, Finland, department of veterinary biosciences,university of helsinki,helsinki, Finland, department of veterinary biosciences,university of helsinki,helsinki, Finland, department of veterinary biosciences,university of helsinki,helsinki, Finland, department of veterinary biosciences,university of helsinki,helsinki,finland,laboratory of microbiology,wageningen university,wageningen,netherlands,infection biology program,department of bacteriology and immunology,haartman institute,university of helsinki,helsinki, Finland
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Authors
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