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dTULP,the Drosophila melanogaster Homolog of Tubby,Regulates Transient Receptor Potential Channel Localization in Cilia
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نویسنده
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park j. ,lee j. ,shim j. ,han w. ,lee j. ,bae y.c. ,chung y.d. ,kim c.h. ,moon s.j.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 9
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چکیده
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Mechanically gated ion channels convert sound into an electrical signal for the sense of hearing. in drosophila melanogaster,several transient receptor potential (trp) channels have been implicated to be involved in this process. trpn (nompc) and trpv (inactive) channels are localized in the distal and proximal ciliary zones of auditory receptor neurons,respectively. this segregated ciliary localization suggests distinct roles in auditory transduction. however,the regulation of this localization is not fully understood. here we show that the drosophila tubby homolog,king tubby (hereafter called dtulp) regulates ciliary localization of trps. dtulp-deficient flies show uncoordinated movement and complete loss of sound-evoked action potentials. inactive and nompc are mislocalized in the cilia of auditory receptor neurons in the dtulp mutants,indicating that dtulp is required for proper cilia membrane protein localization. this is the first demonstration that dtulp regulates trp channel localization in cilia,and suggests that dtulp is a protein that regulates ciliary neurosensory functions. © 2013 park et al.
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آدرس
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department of oral biology,yonsei university college of dentistry,seodaemun-gu,seoul, South Korea, department of life science,university of seoul,seoul, South Korea, department of oral biology,yonsei university college of dentistry,seodaemun-gu,seoul, South Korea, department of pharmacology,brain korea 21 project for medical science,brain research institute,yonsei university college of medicine,seoul, South Korea, yonsei institute of pharmaceutical sciences,college of pharmacy,yonsei university,inchon, South Korea, department of oral anatomy and neurobiology,bk21,school of dentistry,kyungpook national university,daegu, South Korea, department of life science,university of seoul,seoul, South Korea, department of pharmacology,brain korea 21 project for medical science,brain research institute,yonsei university college of medicine,seoul,south korea,severance biomedical science institute,yonsei university college of medicine,seoul, South Korea, department of oral biology,yonsei university college of dentistry,seodaemun-gu,seoul, South Korea
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Authors
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