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Reconstructing the Population Genetic History of the Caribbean
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نویسنده
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moreno-estrada a. ,gravel s. ,zakharia f. ,mccauley j.l. ,byrnes j.k. ,gignoux c.r. ,ortiz-tello p.a. ,martínez r.j. ,hedges d.j. ,morris r.w. ,eng c. ,sandoval k. ,acevedo-acevedo s. ,norman p.j. ,layrisse z. ,parham p. ,martínez-cruzado j.c. ,burchard e.g. ,cuccaro m.l. ,martin e.r. ,bustamante c.d.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 11
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چکیده
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The caribbean basin is home to some of the most complex interactions in recent history among previously diverged human populations. here,we investigate the population genetic history of this region by characterizing patterns of genome-wide variation among 330 individuals from three of the greater antilles (cuba,puerto rico,hispaniola),two mainland (honduras,colombia),and three native south american (yukpa,bari,and warao) populations. we combine these data with a unique database of genomic variation in over 3,000 individuals from diverse european,african,and native american populations. we use local ancestry inference and tract length distributions to test different demographic scenarios for the pre- and post-colonial history of the region. we develop a novel ancestry-specific pca (aspca) method to reconstruct the sub-continental origin of native american,european,and african haplotypes from admixed genomes. we find that the most likely source of the indigenous ancestry in caribbean islanders is a native south american component shared among inland amazonian tribes,central america,and the yucatan peninsula,suggesting extensive gene flow across the caribbean in pre-columbian times. we find evidence of two pulses of african migration. the first pulse-which today is reflected by shorter,older ancestry tracts-consists of a genetic component more similar to coastal west african regions involved in early stages of the trans-atlantic slave trade. the second pulse-reflected by longer,younger tracts-is more similar to present-day west-central african populations,supporting historical records of later transatlantic deportation. surprisingly,we also identify a latino-specific european component that has significantly diverged from its parental iberian source populations,presumably as a result of small european founder population size. we demonstrate that the ancestral components in admixed genomes can be traced back to distinct sub-continental source populations with far greater resolution than previously thought,even when limited pre-columbian caribbean haplotypes have survived. © 2013 moreno-estrada et al.
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آدرس
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department of genetics,stanford university school of medicine,stanford,ca, United States, department of genetics,stanford university school of medicine,stanford,ca,united states,department of human genetics and genome quebec innovation centre,mcgill university,montreal,qc, Canada, department of genetics,stanford university school of medicine,stanford,ca, United States, center for genetic epidemiology and statistical genetics,john p. hussman institute for human genomics,university of miami miller school of medicine,miami,fl, United States, department of genetics,stanford university school of medicine,stanford,ca,united states,ancestry.com dna,llc,san francisco,ca, United States, department of bioengineering and therapeutic sciences,university of california san francisco,california, United States, department of genetics,stanford university school of medicine,stanford,ca, United States, center for genetic epidemiology and statistical genetics,john p. hussman institute for human genomics,university of miami miller school of medicine,miami,fl, United States, center for genetic epidemiology and statistical genetics,john p. hussman institute for human genomics,university of miami miller school of medicine,miami,fl, United States, center for genetic epidemiology and statistical genetics,john p. hussman institute for human genomics,university of miami miller school of medicine,miami,fl, United States, department of bioengineering and therapeutic sciences,university of california san francisco,california, United States, department of genetics,stanford university school of medicine,stanford,ca, United States, department of biology,university of puerto rico at mayaguez,mayaguez, Puerto Rico, department of structural biology,stanford university school of medicine,stanford,ca, United States, center of experimental medicine miguel layrisse,ivic,caracas, Venezuela, department of structural biology,stanford university school of medicine,stanford,ca, United States, department of biology,university of puerto rico at mayaguez,mayaguez, Puerto Rico, department of bioengineering and therapeutic sciences,university of california san francisco,california, United States, center for genetic epidemiology and statistical genetics,john p. hussman institute for human genomics,university of miami miller school of medicine,miami,fl, United States, center for genetic epidemiology and statistical genetics,john p. hussman institute for human genomics,university of miami miller school of medicine,miami,fl, United States, department of genetics,stanford university school of medicine,stanford,ca, United States
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Authors
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