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CRIS-A Novel cAMP-Binding Protein Controlling Spermiogenesis and the Development of Flagellar Bending
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نویسنده
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krähling a.m. ,alvarez l. ,debowski k. ,van q. ,gunkel m. ,irsen s. ,al-amoudi a. ,strünker t. ,kremmer e. ,krause e. ,voigt i. ,wörtge s. ,waisman a. ,weyand i. ,seifert r. ,kaupp u.b. ,wachten d.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 12
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چکیده
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The second messengers camp and cgmp activate their target proteins by binding to a conserved <underline>c</underline>yclic <underline>n</underline>ucleotide-<underline>b</underline>inding <underline>d</underline>omain (cnbd). here,we identify and characterize an entirely novel cnbd-containing protein called cris (<underline>c</underline>yclic nucleotide <underline>r</underline>eceptor <underline>i</underline>nvolved in <underline>s</underline>perm function) that is unrelated to any of the other members of this protein family. cris is exclusively expressed in sperm precursor cells. cris-deficient male mice are either infertile due to a lack of sperm resulting from spermatogenic arrest,or subfertile due to impaired sperm motility. the motility defect is caused by altered ca2+ regulation of flagellar beat asymmetry,leading to a beating pattern that is reminiscent of sperm hyperactivation. our results suggest that cris interacts during spermiogenesis with ca2+-regulated proteins that-in mature sperm-are involved in flagellar bending. © 2013 krähling et al.
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آدرس
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center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, university of göttingen,third institute of physics - biophysics,göttingen, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn,germany,german center for neurodegenerative diseases (dzne),bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of molecular immunology (imi),munich, Germany, leibniz-institut für molekulare pharmakologie (fmp),berlin, Germany, max planck institute for biology of ageing,transgenic core facility,cologne, Germany, institute for molecular medicine,university medical center of the johannes gutenberg-university of mainz,mainz, Germany, institute for molecular medicine,university medical center of the johannes gutenberg-university of mainz,mainz, Germany, institute of complex systems,cellular biophysics (ics-4),forschungszentrum jülich,jülich, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany, center of advanced european studies and research (caesar),department of molecular sensory systems,bonn, Germany
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Authors
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