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Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis
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نویسنده
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guo y. ,tan l.-j. ,lei s.-f. ,yang t.-l. ,chen x.-d. ,zhang f. ,chen y. ,pan f. ,yan h. ,liu x. ,tian q. ,zhang z.-x. ,zhou q. ,qiu c. ,dong s.-s. ,xu x.-h. ,guo y.-f. ,zhu x.-z. ,liu s.-l. ,wang x.-l. ,li x. ,luo y. ,zhang l.-s. ,li m. ,wang j.-t. ,wen t. ,drees b. ,hamilton j. ,papasian c.j. ,recker r.r. ,song x.-p. ,cheng j. ,deng h.-w.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 1
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چکیده
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Osteoporosis is a major public health problem. it is mainly characterized by low bone mineral density (bmd) and/or lowtrauma osteoporotic fractures (of),both of which have strong genetic determination. the specific genes influencing these phenotypic traits,however,are largely unknown. using the affymetrix 500k array set,we performed a case-control genomewide association study (gwas) in 700 elderly chinese han subjects (350 with hip of and 350 healthy matched controls). a follow-up replication study was conducted to validate our major gwas findings in an independent chinese sample containing 390 cases with hip of and 516 controls. we found that a snp,rs13182402 within the aldh7a1 gene on chromosome 5q31,was strongly associated with of with evidence combined gwas and replication studies (p = 2.08×10-9,odds ratio = 2.25). in order to explore the target risk factors and potential mechanism underlying hip of risk,we further examined this candidate snp's relevance to hip bmd both in chinese and caucasian populations involving 9,962 additional subjects. this snp was confirmed as consistently associated with hip bmd even across ethnic boundaries,in both chinese and caucasians (combined p = 6.39×10 -6),further attesting to its potential effect on osteoporosis. aldh7a1 degrades and detoxifies acetaldehyde,which inhibits osteoblast proliferation and results in decreased bone formation. our findings may provide new insights into the pathogenesis of osteoporosis. © 2010 guo et al.
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آدرس
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key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha, China, school of medicine,university of missouri kansas city,kansas city,mo, United States, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, school of medicine,university of missouri kansas city,kansas city,mo, United States, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha, China, molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha, China, molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha, China, molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha, China, school of medicine,university of missouri kansas city,kansas city,mo, United States, department of orthopaedics,school of medicine,xi'an jiaotong university,xi'an, China, department of orthopaedics,school of medicine,xi'an jiaotong university,xi'an, China, department of orthopaedics,xiangya hospital of central south university,changsha,hunan, China, school of medicine,university of missouri kansas city,kansas city,mo, United States, school of medicine,university of missouri kansas city,kansas city,mo, United States, school of medicine,university of missouri kansas city,kansas city,mo, United States, osteoporosis research center,creighton university,omaha,ne, United States, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an, China, national engineering research center for beijing biochip technology,beijing, China, key laboratory of biomedical information engineering of ministry of education,school of life science and technology,xi'an jiaotong university,xi'an,china,institute of molecular genetics,school of life science and technology,xi'an jiaotong university,xi'an,china,molecular and statistical genetics lab.,college of life sciences,hunan normal university,changsha,china,school of medicine,university of missouri kansas city,kansas city,mo,united states,center of systematic biomedical research,shanghai university of science and technology,shanghai, China
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