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A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese
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نویسنده
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tsai f.-j. ,yang c.-f. ,chen c.-c. ,chuang l.-m. ,lu c.-h. ,chang c.-t. ,wang t.-y. ,chen r.-h. ,shiu c.-f. ,liu y.-m. ,chang c.-c. ,chen p. ,chen c.-h. ,fann c.s.j. ,chen y.-t. ,wu j.-y.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 2
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چکیده
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To investigate the underlying mechanisms of t2d pathogenesis,we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (t2d) in a han chinese population. a two-stage genome-wide association (gwa) study was conducted,in which 995 patients and 894 controls were genotyped using the illumina humanhap550-duo beadchip for the first genome scan stage. this was further replicated in 1,803 patients and 1,473 controls in stage 2. we found two loci not previously associated with diabetes susceptibility in and around the genes protein tyrosine phosphatase receptor type d (ptprd) (p = 8.54 × 10-10; odds ratio [or] = 1.57; 95% confidence interval [ci] = 1.36-1.82),and serine racemase (srr) (p = 3.06 × 10-9; or = 1.28; 95% ci = 1.18-1.39). we also confirmed that variants in kcnq1 were associated with t2d risk,with the strongest signal at rs2237895 (p = 9.65 × 10-10; or = 1.29,95% ci = 1.19-1.40). by identifying two novel genetic susceptibility loci in a han chinese population and confirming the involvement of kcnq1,which was previously reported to be associated with t2d in japanese and european descent populations,our results may lead to a better understanding of differences in the molecular pathogenesis of t2d among various populations. © 2010 tsai et al.
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آدرس
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school of post-baccalaureate chinese medicine,china medical university,taichung,taiwan,department of medical genetics,pediatrics and medical research,china medical university hospital,taichung,taiwan,department of biotechnology and bioinformatics,asia university,taichung, Taiwan, institute of biomedical sciences,academia sinica,taipei,taiwan,national genotyping center,academia sinica,taipei, Taiwan, division of endocrinology and metabolism,department of medicine,china medical university hospital,taichung,taiwan,school of chinese medicine,college of chinese medicine,china medical university,taichung, Taiwan, department of internal medicine,national taiwan university hospital,taipei, Taiwan, department of internal medicine,endocrinology and metabolism,chia-yi christian hospital,chia-yi, Taiwan, division of endocrinology and metabolism,department of medicine,china medical university hospital,taichung,taiwan,school of chinese medicine,college of chinese medicine,china medical university,taichung, Taiwan, division of endocrinology and metabolism,department of medicine,china medical university hospital,taichung,taiwan,school of chinese medicine,college of chinese medicine,china medical university,taichung, Taiwan, division of endocrinology and metabolism,department of medicine,china medical university hospital,taichung,taiwan,school of chinese medicine,college of chinese medicine,china medical university,taichung, Taiwan, institute of biomedical sciences,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei,taiwan,national genotyping center,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei,taiwan,national genotyping center,academia sinica,taipei,taiwan,department of pediatrics,duke university medical center,durham,nc, United States, institute of biomedical sciences,academia sinica,taipei,taiwan,national genotyping center,academia sinica,taipei,taiwan,graduate institute of chinese medical science,china medical university,taichung, Taiwan
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Authors
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