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Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
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نویسنده
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pillas d. ,hoggart c.j. ,evans d.m. ,o'reilly p.f. ,sipilä k. ,lähdesmäki r. ,millwood i.y. ,kaakinen m. ,netuveli g. ,blane d. ,charoen p. ,sovio u. ,pouta a. ,freimer n. ,hartikainen a.-l. ,laitinen j. ,vaara s. ,glaser b. ,crawford p. ,timpson n.j. ,ring s.m. ,deng g. ,zhang w. ,mccarthy m.i. ,deloukas p. ,peltonen l. ,elliott p. ,coin l.j.m. ,smith g.d. ,jarvelin m.-r.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 2
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چکیده
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Tooth development is a highly heritable process which relates to other growth and developmental processes,and which interacts with the development of the entire craniofacial complex. abnormalities of tooth development are common,with tooth agenesis being the most common developmental anomaly in humans. we performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 northern finland birth cohort (nfbc1966) and 1,518 individuals from the avon longitudinal study of parents and children (alspac). we identified 5 loci at p<5×10 -8,and 5 with suggestive association (p<5×10-6). the loci included several genes with links to tooth and other organ development (kcnj2,eda,hoxb2,rad51l1,igf2bp1,hmga2,msrb3). genes at four of the identified loci are implicated in the development of cancer. a variant within the hoxb gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. © 2010 pillas et al.
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آدرس
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department of epidemiology and public health,imperial college london,london,united kingdom,economic and social research council,international centre for life course studies in society and health,london,united kingdom,medical research council centre of epidemiology for child health,university college london,institute of child health,london, United Kingdom, department of epidemiology and public health,imperial college london,london, United Kingdom, medical research council centre for causal analyses in translational epidemiology,department of social medicine,university of bristol,bristol, United Kingdom, department of epidemiology and public health,imperial college london,london, United Kingdom, department of prosthetic dentistry and stomatognathic physiology,institute of dentistry,university of oulu,oulu,finland,oral and maxillofacial department,oulu university hospital,oulu, Finland, oral and maxillofacial department,oulu university hospital,oulu,finland,department of oral development and orthodontics,institute of dentistry,university of oulu,oulu, Finland, department of epidemiology and public health,imperial college london,london,united kingdom,clinical trial service unit and epidemiological studies unit (ctsu),university of oxford,oxford, United Kingdom, institute of health sciences,university of oulu,oulu,finland,biocenter oulu,university of oulu,oulu, Finland, economic and social research council,international centre for life course studies in society and health,london,united kingdom,department of primary care and social medicine,faculty of medicine,imperial college london, United Kingdom, economic and social research council,international centre for life course studies in society and health,london,united kingdom,department of primary care and social medicine,faculty of medicine,imperial college london, United Kingdom, department of epidemiology and public health,imperial college london,london,united kingdom,department of tropical hygiene,faculty of tropical medicine,mahidol university,bangkok, Thailand, department of epidemiology and public health,imperial college london,london, United Kingdom, department of lifecourse and services,national institute of health and welfare,oulu, Finland, center for neurobehavioral genetics,university of california los angeles,los angeles,ca,united states,jane and terry semel institute for neuroscience and human behavior,los angeles,ca,united states,department of psychiatry,university of california los angeles,los angeles,ca, United States, department of clinical sciences/obstetrics and gynecology,university of oulu,oulu, Finland, finnish institute of occupational health,oulu, Finland, department of lifecourse and services,national institute of health and welfare,oulu, Finland, medical research council centre for causal analyses in translational epidemiology,department of social medicine,university of bristol,bristol, United Kingdom, department of oral and dental science,university of bristol,bristol, United Kingdom, medical research council centre for causal analyses in translational epidemiology,department of social medicine,university of bristol,bristol, United Kingdom, avon longitudinal study of parents and children (alspac),university of bristol,bristol, United Kingdom, department of gastroenterology and hepatology,imperial college london,london, United Kingdom, department of epidemiology and public health,imperial college london,london, United Kingdom, oxford centre for diabetes,endocrinology and metabolism (ocdem),university of oxford,oxford,united kingdom,wellcome trust centre for human genetics,university of oxford,roosevelt drive,headington,oxford, United Kingdom, wellcome trust sanger institute,welcome trust genome campus,hinxton,cambridge, United Kingdom, wellcome trust sanger institute,welcome trust genome campus,hinxton,cambridge,united kingdom,institute of molecular medicine finland fimm,nordic embl partnership for molecular medicine,helsinki,finland,department of medical genetics,university of helsinki,helsinki,finland,national institute for health and welfare,public health genomics unit,helsinki, Finland, department of epidemiology and public health,imperial college london,london,united kingdom,medical research council-health protection agency centre in environment and health,london, United Kingdom, department of epidemiology and public health,imperial college london,london, United Kingdom, medical research council centre for causal analyses in translational epidemiology,department of social medicine,university of bristol,bristol, United Kingdom, department of epidemiology and public health,imperial college london,london,united kingdom,institute of health sciences,university of oulu,oulu,finland,biocenter oulu,university of oulu,oulu,finland,department of lifecourse and services,national institute of health and welfare,oulu, Finland
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