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Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT,a cancer susceptibility Hot-Spot
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نویسنده
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johnatty s.e. ,beesley j. ,chen x. ,macgregor s. ,duffy d.l. ,spurdle a.b. ,de fazio a. ,gava n. ,webb p.m. ,rossing m.a. ,doherty j.a. ,goodman m.t. ,lurie g. ,thompson p.j. ,wilkens l.r. ,ness r.b. ,moysich k.b. ,chang-claude j. ,wang-gohrke s. ,cramer d.w. ,terry k.l. ,hankinson s.e. ,tworoger s.s. ,garcia-closas m. ,yang h. ,lissowska j. ,chanock s.j. ,pharoah p.d. ,song h. ,whitemore a.s. ,pearce c.l. ,stram d.o. ,wu a.h. ,pike m.c. ,gayther s.a. ,ramus s.j. ,menon u. ,gentry-maharaj a. ,anton-culver h. ,ziogas a. ,hogdall e. ,kjaer s.k. ,hogdall c. ,berchuck a. ,schildkraut j.m. ,iversen e.s. ,moorman p.g. ,phelan c.m. ,sellers t.a. ,cunningham j.m. ,vierkant r.a. ,rider d.n. ,goode e.l. ,haviv i. ,chenevix-trench g.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 7 - صفحه:1 -10
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چکیده
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We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. we therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (snps) in 173 genes involved in stromal epithelial interactions in the ovarian cancer association consortium (ocac). in the discovery stage,cases with epithelial ovarian cancer (n = 675) and controls (n = 1,162) were genotyped at 1,536 snps using an illumina goldengate assay. based on positive predictive value estimates,three snps-podxl rs1013368,itga6 rs13027811,and mmp3 rs522616-were selected for replication using taqman genotyping in up to 3,059 serous invasive cases and 8,905 controls from 16 ocac case-control studies. an additional 18 snps with pper-allele<0.05 in the discovery stage were selected for replication in a subset of five ocac studies (n = 1,233 serous invasive cases; n = 3,364 controls). the discovery stage associations in podxl,itga6,and mmp3 were attenuated in the larger replication set (adj. pper-allele≥0.5). however genotypes at tert rs7726159 were associated with ovarian cancer risk in the smaller,five-study replication study (pper-allele = 0.03). combined analysis of the discovery and replication sets for this tert snp showed an increased risk of serous ovarian cancer among non-hispanic whites [adj. orper-allele 1.14 (1.04-1.24) p = 0.003]. our study adds to the growing evidence that,like the 8q24 locus,the telomerase reverse transcriptase locus at 5p15.33,is a general cancer susceptibility locus. © 2010 johnatty et al.
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آدرس
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queensland institute of medical research,brisbane, Australia, queensland institute of medical research,brisbane, Australia, queensland institute of medical research,brisbane, Australia, queensland institute of medical research,brisbane, Australia, queensland institute of medical research,brisbane, Australia, queensland institute of medical research,brisbane, Australia, department of gynaecological oncology and westmead institute for cancer research,university of sydney at the westmead millennium institute,westmead hospital,sydney, Australia, department of gynaecological oncology and westmead institute for cancer research,university of sydney at the westmead millennium institute,westmead hospital,sydney, Australia, peter maccallum cancer centre,east melbourne, Australia, epidemiology program,division of public health services,fred hutchinson cancer research center,seattle,wa, United States, epidemiology program,division of public health services,fred hutchinson cancer research center,seattle,wa, United States, cancer research center of hawaii,university of hawaii,hilo,hi, United States, cancer research center of hawaii,university of hawaii,hilo,hi, United States, cancer research center of hawaii,university of hawaii,hilo,hi, United States, cancer research center of hawaii,university of hawaii,hilo,hi, United States, university of texas school of public health,houston,tx, United States, roswell park cancer center,buffalo,ny, United States, unit of genetic epidemiology,division of cancer epidemiology,deutsches krebsforschungszentrum,heidelberg, Germany, department of obstetrics and gynecology,university of ulm,ulm, Germany, obstetrics and gynecology epidemiology center,brigham and women's hospital,boston,ma, United States, obstetrics and gynecology epidemiology center,brigham and women's hospital,boston,ma, United States, channing laboratory,department of medicine,brigham and women's hospital and harvard medical school,boston,ma,united states,department of epidemiology,harvard school of public health,boston,ma, United States, channing laboratory,department of medicine,brigham and women's hospital and harvard medical school,boston,ma,united states,department of epidemiology,harvard school of public health,boston,ma, United States, national cancer institute,division of cancer epidemiology and genetics,rockville,md, United States, national cancer institute,division of cancer epidemiology and genetics,rockville,md, United States, department of cancer epidemiology and prevention,the m. sklodowska-curie cancer center and institute of oncology,warsaw, Poland, laboratory of translational genomics division of cancer epidemiology and genetics,core genotyping facility division of cancer epidemiology and genetics,national cancer institute,bethesda,md, United States, department of oncology and public health and primary care,university of cambridge,cambridge, United Kingdom, department of oncology and public health and primary care,university of cambridge,cambridge, United Kingdom, department of health research and policy,stanford university school of medicine,stanford,ca, United States, department of preventative medicine,keck school of medicine,university of southern california norris comprehensive cancer center,los angeles,ca, United States, department of preventative medicine,keck school of medicine,university of southern california norris comprehensive cancer center,los angeles,ca, United States, department of preventative medicine,keck school of medicine,university of southern california norris comprehensive cancer center,los angeles,ca, United States, department of preventative medicine,keck school of medicine,university of southern california norris comprehensive cancer center,los angeles,ca, United States, department of gynaecological oncology,ucl ega institute for women's health,university college london,london, United Kingdom, department of gynaecological oncology,ucl ega institute for women's health,university college london,london, United Kingdom, department of gynaecological oncology,ucl ega institute for women's health,university college london,london, United Kingdom, department of gynaecological oncology,ucl ega institute for women's health,university college london,london, United Kingdom, department of epidemiology,school of medicine,university of california irvine,irvine,ca, United States, department of epidemiology,school of medicine,university of california irvine,irvine,ca, United States, department of virus,hormones,and cancer,institute of cancer epidemiology,danish cancer society,copenhagen, Denmark, department of virus,hormones,and cancer,institute of cancer epidemiology,danish cancer society,copenhagen,denmark,gynaecologic clinic,the juliane marie centre,righosptalet,university of copenhagen,copenhagen, Denmark, gynaecologic clinic,the juliane marie centre,righosptalet,university of copenhagen,copenhagen, Denmark, division of preventative medicine,the duke comprehensive cancer center,durham,nc, United States, division of preventative medicine,the duke comprehensive cancer center,durham,nc, United States, division of preventative medicine,the duke comprehensive cancer center,durham,nc, United States, division of preventative medicine,the duke comprehensive cancer center,durham,nc, United States, division of cancer prevention and control,h. lee moffitt cancer center and research institute,magnolia drive,tampa,fl, United States, division of cancer prevention and control,h. lee moffitt cancer center and research institute,magnolia drive,tampa,fl, United States, department of health sciences research,mayo clinic college of medicine,rochester,mn, United States, department of health sciences research,mayo clinic college of medicine,rochester,mn, United States, department of health sciences research,mayo clinic college of medicine,rochester,mn, United States, department of health sciences research,mayo clinic college of medicine,rochester,mn, United States, the blood and dna profiling facility,baker idi,melbourne,australia,department of biochemistry,school of medicine,university of melbourne,parkville, Australia, queensland institute of medical research,brisbane, Australia
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Authors
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