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Identification of new genetic risk variants for Type 2 Diabetes
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نویسنده
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shu x.o. ,long j. ,cai q. ,qi l. ,xiang y.-b. ,cho y.s. ,tai e.s. ,li x. ,lin x. ,chow w.-h. ,go m.j. ,seielstad m. ,bao w. ,li h. ,cornelis m.c. ,yu k. ,wen w. ,shi j. ,han b.-g. ,sim x.l. ,liu l. ,qi q. ,kim h.-l. ,ng d.p.k. ,lee j.-y. ,kim y.j. ,li c. ,gao y.-t. ,zheng w. ,hu f.b.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 9
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چکیده
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Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (t2d),most reported variants have small to moderate effects and account for only a small proportion of the heritability of t2d,suggesting that the majority of inter-person genetic variation in this disease remains to be determined. we conducted a multistage,genome-wide association study (gwas) within the asian consortium of diabetes to search for t2d susceptibility markers. from 590,887 snps genotyped in 1,019 t2d cases and 1,710 controls selected from chinese women in shanghai,we selected the top 2,100 snps that were not in linkage disequilibrium (r2<0.2) with known t2d loci for in silico replication in three t2d gwas conducted among european americans,koreans,and singapore chinese. the 5 most promising snps were genotyped in an independent set of 1,645 cases and 1,649 controls from shanghai,and 4 of them were further genotyped in 1,487 cases and 3,316 controls from 2 additional chinese studies. consistent associations across all studies were found for rs1359790 (13q31.1),rs10906115 (10p13),and rs1436955 (15q22.2) with p-values (per allele or,95%ci) of 6.49×10-9 (1.15,1.10-1.20),1.45×10-8 (1.13,1.08-1.18),and 7.14×10-7 (1.13,1.08-1.19),respectively,in combined analyses of 9,794 cases and 14,615 controls. our study provides strong evidence for a novel t2d susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous gwas.
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آدرس
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division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, departments of epidemiology and nutrition,harvard university school of public health,boston,ma, United States, department of epidemiology,shanghai cancer institute,shanghai, China, center for genome science,korea national institute of health,seoul, South Korea, department of medicine,yong loo lin school of medicine,national university of singapore,singapore,singapore,department of epidemiology and public health,yong loo lin school of medicine,national university of singapore,singapore,singapore,duke-national university of singapore graduate medical school,singapore, Singapore, department of nutrition and food hygiene and moe key lab of environment and health,school of public health,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of nutrition and metabolism,institute for nutritional sciences,shanghai institutes for biological sciences,chinese academy of sciences and graduate school of the chinese academy of sciences,shanghai, China, division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, center for genome science,korea national institute of health,seoul, South Korea, genome institute of singapore,singapore, Singapore, department of nutrition and food hygiene and moe key lab of environment and health,school of public health,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of nutrition and metabolism,institute for nutritional sciences,shanghai institutes for biological sciences,chinese academy of sciences and graduate school of the chinese academy of sciences,shanghai, China, departments of epidemiology and nutrition,harvard university school of public health,boston,ma, United States, division of cancer epidemiology and genetics,national cancer institute,rockville,md, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, center for genome science,korea national institute of health,seoul, South Korea, genome institute of singapore,singapore, Singapore, department of nutrition and food hygiene and moe key lab of environment and health,school of public health,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of nutrition and metabolism,institute for nutritional sciences,shanghai institutes for biological sciences,chinese academy of sciences and graduate school of the chinese academy of sciences,shanghai, China, center for genome science,korea national institute of health,seoul, South Korea, department of epidemiology and public health,yong loo lin school of medicine,national university of singapore,singapore, Singapore, center for genome science,korea national institute of health,seoul, South Korea, center for genome science,korea national institute of health,seoul, South Korea, department of biostatistics,vanderbilt university school of medicine,nashville,tn, United States, department of epidemiology,shanghai cancer institute,shanghai, China, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, departments of epidemiology and nutrition,harvard university school of public health,boston,ma, United States
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Authors
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