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Longitudinal genome-wide association of cardiovascular disease risk factors in the bogalusa heart study
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نویسنده
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smith e.n. ,chen w. ,kähönen m. ,kettunen j. ,lehtimäki t. ,peltonen l. ,raitakari o.t. ,salem r.m. ,schork n.j. ,shaw m. ,srinivasan s.r. ,topol e.j. ,viikari j.s. ,berenson g.s. ,murray s.s.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 9
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چکیده
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Cardiovascular disease (cvd) is the leading cause of death worldwide. recent genome-wide association (gwa) studies have pinpointed many loci associated with cvd risk factors in adults. it is unclear,however,if these loci predict trait levels at all ages,if they are associated with how a trait develops over time,or if they could be used to screen individuals who are presymptomatic to provide the opportunity for preventive measures before disease onset. we completed a genome-wide association study on participants in the longitudinal bogalusa heart study (bhs) and have characterized the association between genetic factors and the development of cvd risk factors from childhood to adulthood. we report 7 genome-wide significant associations involving cvd risk factors,two of which have been previously reported. top regions were tested for replication in the young finns study (yf) and two associations strongly replicated: rs247616 in cetp with hdl levels (combined p = 9.7 × 10-24),and rs445925 at apoe with ldl levels (combined p = 8.7 × 10-19). we show that snps previously identified in adult cross-sectional studies tend to show age-independent effects in the bhs with effect sizes consistent with previous reports. previously identified variants were associated with adult trait levels above and beyond those seen in childhood; however,variants with time-dependent effects were also promising predictors. this is the first gwa study to evaluate the role of common genetic variants in the development of cvd risk factors in children as they advance through adulthood and highlights the utility of using longitudinal studies to identify genetic predictors of adult traits in children. © 2010 smith et al.
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آدرس
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scripps genomic medicine and scripps translational science institute,la jolla,ca, United States, department of epidemiology,tulane university,new orleans,la, United States, department of clinical physiology,university hospital of tampere and university of tampere medical school,tampere, Finland, wellcome trust sanger institute,wellcome trust genome campus,hinxton,cambridge,united kingdom,fimm,institute for molecular medicine finland,helsinki, Finland, department of clinical chemistry,university hospital of tampere and university of tampere medical school,tampere, Finland, wellcome trust sanger institute,wellcome trust genome campus,hinxton,cambridge,united kingdom,fimm,institute for molecular medicine finland,helsinki,finland,the broad institute of mit and harvard,boston,ma, United States, department of clinical physiology,turku university hospital and centre of applied and preventive cardiovascular medicine,university of turku,turku, Finland, the broad institute of mit and harvard,boston,ma, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca, United States, department of epidemiology,tulane university,new orleans,la, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca, United States, department of medicine,university of turku and turku university hospital,turku, Finland, department of epidemiology,tulane university,new orleans,la, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca, United States
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Authors
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