|
|
|
|
Gimap3 regulates tissue-specific mitochondrial DNA segregation
|
|
|
|
|
|
|
|
نویسنده
|
jokinen r. ,marttinen p. ,sandell h.k. ,manninen t. ,teerenhovi h. ,wai t. ,teoli d. ,loredo-osti j.c. ,shoubridge e.a. ,battersby b.j.
|
|
منبع
|
plos genetics - 2010 - دوره : 6 - شماره : 10 - صفحه:1 -9
|
|
چکیده
|
Mitochondrial dna (mtdna) sequence variants segregate in mutation and tissue-specific manners,but the mechanisms remain unknown. the segregation pattern of pathogenic mtdna mutations is a major determinant of the onset and severity of disease. using a heteroplasmic mouse model,we demonstrate that gimap3,an outer mitochondrial membrane gtpase,is a critical regulator of this process in leukocytes. gimap3 is important for t cell development and survival,suggesting that leukocyte survival may be a key factor in the genetic regulation of mtdna sequence variants and in modulating human mitochondrial diseases. © 2010 jokinen et al.
|
|
|
|
|
آدرس
|
molecular neurology and institute of biomedicine,biomedicum helsinki,university of helsinki,helsinki, Finland, molecular neurology and institute of biomedicine,biomedicum helsinki,university of helsinki,helsinki, Finland, molecular neurology and institute of biomedicine,biomedicum helsinki,university of helsinki,helsinki, Finland, molecular neurology and institute of biomedicine,biomedicum helsinki,university of helsinki,helsinki, Finland, molecular neurology and institute of biomedicine,biomedicum helsinki,university of helsinki,helsinki, Finland, montreal neurological institute and department of human genetics,mcgill university,montreal,qc, Canada, montreal neurological institute and department of human genetics,mcgill university,montreal,qc, Canada, department of mathematics and statistics,memorial university,st. john's,nl, Canada, montreal neurological institute and department of human genetics,mcgill university,montreal,qc, Canada, molecular neurology and institute of biomedicine,biomedicum helsinki,university of helsinki,helsinki, Finland
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|