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Genome-Wide association study of coronary heart disease and its risk factors in 8,090 african americans: the nhlbi CARe project
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نویسنده
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lettre g. ,palmer c.d. ,young t. ,ejebe k.g. ,allayee h. ,benjamin e.j. ,bennett f. ,bowden d.w. ,chakravarti a. ,dreisbach a. ,farlow d.n. ,folsom a.r. ,fornage m. ,forrester t. ,fox e. ,haiman c.a. ,hartiala j. ,harris t.b. ,hazen s.l. ,heckbert s.r. ,henderson b.e. ,hirschhorn j.n. ,keating b.j. ,kritchevsky s.b. ,larkin e. ,li m. ,rudock m.e. ,mckenzie c.a. ,meigs j.b. ,meng y.a. ,mosley jr. t.h. ,newman a.b. ,newton-cheh c.h. ,paltoo d.n. ,papanicolaou g.j. ,patterson n. ,post w.s. ,psaty b.m. ,qasim a.n. ,qu l. ,rader d.j. ,redline s. ,reilly m.p. ,reiner a.p. ,rich s.s. ,rotter j.i. ,liu y. ,shrader p. ,siscovick d.s. ,tang w.h.w. ,taylor jr. h.a. ,tracy r.p. ,vasan r.s. ,waters k.m. ,wilks r. ,wilson j.g. ,fabsitz r.r. ,gabriel s.b. ,kathiresan s. ,boerwinkle e.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 2
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چکیده
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Coronary heart disease (chd) is the leading cause of mortality in african americans. to identify common genetic polymorphisms associated with chd and its risk factors (ldl- and hdl-cholesterol (ldl-c and hdl-c),hypertension,smoking,and type-2 diabetes) in individuals of african ancestry,we performed a genome-wide association study (gwas) in 8,090 african americans from five population-based cohorts. we replicated 17 loci previously associated with chd or its risk factors in caucasians. for five of these regions (chd: cdkn2a/cdkn2b; hdl-c: fads1-3,pltp,lpl,and abca1),we could leverage the distinct linkage disequilibrium (ld) patterns in african americans to identify dna polymorphisms more strongly associated with the phenotypes than the previously reported index snps found in caucasian populations. we also developed a new approach for association testing in admixed populations that uses allelic and local ancestry variation. using this method,we discovered several loci that would have been missed using the basic allelic and global ancestry information only. our conclusions suggest that no major loci uniquely explain the high prevalence of chd in african americans. our project has developed resources and methods that address both admixture- and snp-association to maximize power for genetic discovery in even larger african-american consortia.
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آدرس
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montreal heart institute,montréal,canada,département de médecine,université de montréal,montréal, Canada, program in medical and population genetics,broad institute,cambridge,ma,united states,divisions of genetics,endocrinology and program in genomics,children's hospital boston,boston,ma, United States, program in medical and population genetics,broad institute,cambridge,ma, United States, program in medical and population genetics,broad institute,cambridge,ma, United States, department of preventive medicine,university of southern california keck school of medicine,los angeles,ca, United States, department of medicine,boston university schools of medicine and epidemiology,boston,ma,united states,framingham heart study of the national,heart,lung,and blood institute,boston university,framingham,ma, United States, tropical medicine research institute,university of the west indies,kingston, Jamaica, wake forest university school of medicine,winston-salem,nc, United States, mckusick-nathans institute of genetic medicine,johns hopkins university school of medicine,baltimore,md, United States, department of medicine,university of mississipi medical center,jackson,ms, United States, program in medical and population genetics,broad institute,cambridge,ma, United States, division of epidemiology and community health,university of minnesota,minneapolis,mn, United States, institute of molecular medicine,division of epidemiology school of public health,university of texas health sciences center at houston,houston,tx, United States, tropical medicine research institute,university of the west indies,kingston, Jamaica, department of medicine,university of mississipi medical center,jackson,ms, United States, department of preventive medicine,university of southern california keck school of medicine,los angeles,ca, United States, department of preventive medicine,university of southern california keck school of medicine,los angeles,ca, United States, laboratory of epidemiology,demography,and biometry,national institute on aging,bethesda,md, United States, departments of cell biology and cardiovascular medicine,the center for cardiovascular diagnostics and prevention,cleveland clinic,cleveland,oh, United States, departments of medicine and epidemiology,university of washington,seattle,wa,united states,cardiovascular health research unit,university of washington,seattle,wa,united states,group health research institute,group health cooperative,seattle,wa, United States, department of preventive medicine,university of southern california keck school of medicine,los angeles,ca, United States, program in medical and population genetics,broad institute,cambridge,ma,united states,divisions of genetics,endocrinology and program in genomics,children's hospital boston,boston,ma,united states,department of medicine,harvard medical school,boston,ma, United States, center for applied genomics,children's hospital of philadelphia,philadelphia,pa, United States, j. paul sticht center on aging,division of gerontology and geriatric medicine,wake forest university school of medicine,winston-salem,nc, United States, case western reserve university,center for clinical investigation,cleveland,oh, United States, biostatistics and epidemiology,university of pennsylvania,philadelphia,pa, United States, department of epidemiology and prevention,division of public health sciences,wake forest university school of medicine,winston-salem,nc, United States, tropical metabolism research unit,tropical medicine research institute,university of the west indies,kingston, Jamaica, department of medicine,harvard medical school,boston,ma,united states,general medicine division,massachusetts general hospital,boston,ma, United States, program in medical and population genetics,broad institute,cambridge,ma, United States, department of medicine,university of mississipi medical center,jackson,ms, United States, center for aging and population health,department of epidemiology,university of pittsburgh,pittsburgh,pa, United States, program in medical and population genetics,broad institute,cambridge,ma,united states,framingham heart study of the national,heart,lung,and blood institute,boston university,framingham,ma,united states,department of medicine,harvard medical school,boston,ma,united states,center for human genetic research,massachusetts general hospital,boston,ma,united states,cardiovascular research center and cardiology division,massachusetts general hospital,boston,ma, United States, national heart,lung,and blood institute (nhlbi),division of cardiovascular sciences,national institutes of health,bethesda,md, United States, national heart,lung,and blood institute (nhlbi),division of cardiovascular sciences,national institutes of health,bethesda,md, United States, program in medical and population genetics,broad institute,cambridge,ma, United States, division of cardiology,the johns hopkins university school of medicine,baltimore,md, United States, departments of medicine and epidemiology,university of washington,seattle,wa,united states,cardiovascular health research unit,university of washington,seattle,wa,united states,group health research institute,group health cooperative,seattle,wa, United States, the cardiovascular institute,university of pennsylvania,philadelphia,pennsylvania, United States, biostatistics and epidemiology,university of pennsylvania,philadelphia,pa, United States, the cardiovascular institute,university of pennsylvania,philadelphia,pennsylvania,united states,the institute for translational medicine and therapeutics,school of medicine,university of pennsylvania,philadelphia,pa, United States, biostatistics and epidemiology,university of pennsylvania,philadelphia,pa, United States, the cardiovascular institute,university of pennsylvania,philadelphia,pennsylvania,united states,the institute for translational medicine and therapeutics,school of medicine,university of pennsylvania,philadelphia,pa, United States, department of epidemiology,university of washington,seattle,wa, United States, center for public health genomics,university of virginia,charlottesville,va, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, department of epidemiology and prevention,division of public health sciences,wake forest university school of medicine,winston-salem,nc, United States, general medicine division,massachusetts general hospital,boston,ma, United States, departments of medicine and epidemiology,university of washington,seattle,wa,united states,cardiovascular health research unit,university of washington,seattle,wa, United States, departments of cell biology and cardiovascular medicine,the center for cardiovascular diagnostics and prevention,cleveland clinic,cleveland,oh, United States, department of medicine,university of mississipi medical center,jackson,ms,united states,jackson state university,jackson,ms,united states,tougaloo college,tougaloo,ms, United States, departments of pathology and biochemistry,university of vermont,colchester,vt, United States, department of medicine,boston university schools of medicine and epidemiology,boston,ma,united states,framingham heart study of the national,heart,lung,and blood institute,boston university,framingham,ma, United States, department of preventive medicine,university of southern california keck school of medicine,los angeles,ca, United States, epidemiology research unit,tropical medicine research institute,university of the west indies,kingston, Jamaica, department of medicine,university of mississipi medical center,jackson,ms,united states,g. v. (sonny) montgomery veterans affairs medical center,jackson,ms, United States, national heart,lung,and blood institute (nhlbi),division of cardiovascular sciences,national institutes of health,bethesda,md, United States, program in medical and population genetics,broad institute,cambridge,ma, United States, program in medical and population genetics,broad institute,cambridge,ma,united states,framingham heart study of the national,heart,lung,and blood institute,boston university,framingham,ma,united states,department of medicine,harvard medical school,boston,ma,united states,center for human genetic research,massachusetts general hospital,boston,ma,united states,cardiovascular research center and cardiology division,massachusetts general hospital,boston,ma, United States, human genetics center and institute of molecular medicine,division of epidemiology,university of texas health science center,houston,tx, United States
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Authors
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