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Genome-Wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes
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نویسنده
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smith e.n. ,koller d.l. ,panganiban c. ,szelinger s. ,zhang p. ,badner j.a. ,barrett t.b. ,berrettini w.h. ,bloss c.s. ,byerley w. ,coryell w. ,edenberg h.j. ,foroud t. ,gershon e.s. ,greenwood t.a. ,guo y. ,hipolito m. ,keating b.j. ,lawson w.b. ,liu c. ,mahon p.b. ,mcinnis m.g. ,mcmahon f.j. ,mckinney r. ,murray s.s. ,nievergelt c.m. ,nurnberger jr. j.i. ,nwulia e.a. ,potash j.b. ,rice j. ,schulze t.g. ,scheftner w.a. ,shilling p.d. ,zandi p.p. ,zöllner s. ,craig d.w. ,schork n.j. ,kelsoe j.r.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 6
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چکیده
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Although a highly heritable and disabling disease,bipolar disorder's (bd) genetic variants have been challenging to identify. we present new genotype data for 1,190 cases and 401 controls and perform a genome-wide association study including additional samples for a total of 2,191 cases and 1,434 controls. we do not detect genome-wide significant associations for individual loci; however,across all snps,we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (p = 1.5×10-7). to demonstrate that this result is not likely to be a false positive,we analyze replication rates in a large meta-analysis of height and show that,in a large enough study,associations replicate as a function of power,approaching a linear relationship. within bd,snps near exons exhibit a greater probability of replication,supporting an enrichment of reproducible associations near functional regions of genes. these results indicate that there is likely common genetic variation associated with bd near exons (±10 kb) that could be identified in larger studies and,further,provide a framework for assessing the potential for replication when combining results from multiple studies.
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آدرس
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scripps genomic medicine and scripps translational science institute,la jolla,ca,united states,department of pediatrics and rady's children's hospital,school of medicine,university of california san diego,la jolla,ca,united states,scripps health,la jolla,ca, United States, department of medical and molecular genetics,indiana university school of medicine,indianapolis,in, United States, neurogenomics division,the translational genomics research institute,phoenix,az, United States, neurogenomics division,the translational genomics research institute,phoenix,az, United States, department of psychiatry,university of michigan,ann arbor,mi, United States, department of psychiatry,university of chicago,chicago,il, United States, department of psychiatry,portland va medical center,portland,or, United States, department of psychiatry,university of pennsylvania,philadelphia,pa, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca,united states,scripps health,la jolla,ca, United States, department of psychiatry,university of california san francisco,san francisco,ca, United States, department of psychiatry,university of iowa,iowa city,ia, United States, department of medical and molecular genetics,indiana university school of medicine,indianapolis,in,united states,department of biochemistry and molecular biology,indiana university school of medicine,indianapolis,in, United States, department of medical and molecular genetics,indiana university school of medicine,indianapolis,in, United States, department of psychiatry,university of chicago,chicago,il, United States, department of psychiatry,university of california san diego,la jolla,ca, United States, center for applied genomics,abramson research center,the children's hospital of philadelphia,philadelphia,pa,united states,beijing genomics institute at shenzhen,shenzhen, China, department of psychiatry,howard university,washington,dc, United States, cardiovascular institute,university of pennsylvania school of medicine,philadelphia,pa,united states,the institute for translational medicine and therapeutics,school of medicine,university of pennsylvania,philadelphia,pa, United States, department of psychiatry,howard university,washington,dc, United States, department of psychiatry,university of chicago,chicago,il, United States, department of psychiatry,johns hopkins school of medicine,baltimore,md, United States, department of psychiatry,university of michigan,ann arbor,mi, United States, mood and anxiety section,human genetics branch,national institute of mental health intramural research program,national institutes of health,united states department of health and human services,bethesda,md, United States, department of psychiatry,university of california san diego,la jolla,ca, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca,united states,scripps health,la jolla,ca, United States, department of psychiatry,university of california san diego,la jolla,ca, United States, department of psychiatry,indiana university school of medicine,indianapolis,in, United States, department of psychiatry,howard university,washington,dc, United States, department of psychiatry,johns hopkins school of medicine,baltimore,md, United States, division of biostatistics,washington university,st. louis,mo, United States, mood and anxiety section,human genetics branch,national institute of mental health intramural research program,national institutes of health,united states department of health and human services,bethesda,md,united states,department of psychiatry and psychotherapy,georg-august-university göttingen,göttingen, Germany, department of psychiatry,rush university,chicago,il, United States, department of psychiatry,university of california san diego,la jolla,ca, United States, department of psychiatry,johns hopkins school of medicine,baltimore,md, United States, department of psychiatry,university of michigan,ann arbor,mi, United States, neurogenomics division,the translational genomics research institute,phoenix,az, United States, scripps genomic medicine and scripps translational science institute,la jolla,ca,united states,department of molecular and experimental medicine,the scripps research institute,la jolla,ca, United States, department of psychiatry,university of california san diego,la jolla,ca,united states,department of psychiatry,va san diego healthcare system,la jolla,ca, United States
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Authors
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