|
|
|
|
Genetic loci associated with plasma phospholipid N-3 fatty acids: A Meta-Analysis of Genome-Wide association studies from the charge consortium
|
|
|
|
|
|
|
|
نویسنده
|
lemaitre r.n. ,tanaka t. ,tang w. ,manichaikul a. ,foy m. ,kabagambe e.k. ,nettleton j.a. ,king i.b. ,weng l.-c. ,bhattacharya s. ,bandinelli s. ,bis j.c. ,rich s.s. ,jacobs d.r. ,cherubini a. ,mcknight b. ,liang s. ,gu x. ,rice k. ,laurie c.c. ,lumley t. ,browning b.l. ,psaty b.m. ,chen y.-d.i. ,friedlander y. ,djousse l. ,wu j.h.y. ,siscovick d.s. ,uitterlinden a.g. ,arnett d.k. ,ferrucci l. ,fornage m. ,tsai m.y. ,mozaffarian d. ,steffen l.m.
|
|
منبع
|
plos genetics - 2011 - دوره : 7 - شماره : 7
|
|
چکیده
|
Long-chain n-3 polyunsaturated fatty acids (pufas) can derive from diet or from α-linolenic acid (ala) by elongation and desaturation. we investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 pufas by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of european ancestry. minor alleles of snps in fads1 and fads2 (desaturases) were associated with higher levels of ala (p = 3×10 -64) and lower levels of eicosapentaenoic acid (epa,p = 5×10 -58) and docosapentaenoic acid (dpa,p = 4×10 -154). minor alleles of snps in elovl2 (elongase) were associated with higher epa (p = 2×10 -12) and dpa (p = 1×10 -43) and lower docosahexaenoic acid (dha,p = 1×10 -15). in addition to genes in the n-3 pathway,we identified a novel association of dpa with several snps in gckr (glucokinase regulator,p = 1×10 -8). we observed a weaker association between ala and epa among carriers of the minor allele of a representative snp in fads2 (rs1535),suggesting a lower rate of ala-to-epa conversion in these subjects. in samples of african,chinese,and hispanic ancestry,associations of n-3 pufas were similar with a representative snp in fads1 but less consistent with a representative snp in elovl2. our findings show that common variation in n-3 metabolic pathway genes and in gckr influences plasma phospholipid levels of n-3 pufas in populations of european ancestry and,for fads1,in other ancestries.
|
|
|
|
|
آدرس
|
cardiovascular health research unit,department of medicine,university of washington,seattle,wa, United States, clinical research branch,national institute on aging,national institutes of health,baltimore,md, United States, division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States, center for public health genomics,division of biostatistics and epidemiology,university of virginia,charlottesville,va, United States, institute of molecular medicine,university of texas health science center at houston,houston,tx, United States, department of epidemiology,university of alabama at birmingham,birmingham,al, United States, division of epidemiology,human genetics,and environmental sciences,university of texas health science center at houston,houston,tx, United States, department of internal medicine,university of new mexico,albuquerque,nm, United States, division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States, duke global health institute,duke university,durham,nc, United States, geriatric unit,azienda sanitaria firenze (asf),florence, Italy, cardiovascular health research unit,department of medicine,university of washington,seattle,wa, United States, center for public health genomics,university of virginia,charlottesville,va, United States, division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States, institute of gerontology and geriatrics,department of clinical and experimental medicine,university of perugia,perugia, Italy, department of biostatistics,school of public health,university of washington,seattle,wa, United States, laboratory medicine and pathology,university of minnesota,minneapolis,mn, United States, institute of molecular medicine,university of texas health science center at houston,houston,tx, United States, department of biostatistics,school of public health,university of washington,seattle,wa, United States, department of biostatistics,school of public health,university of washington,seattle,wa, United States, department of statistics,university of auckland,auckland, New Zealand, department of medicine,division of medical genetics,university of washington,seattle,wa, United States, cardiovascular health research unit,department of medicine,university of washington,seattle,wa,united states,departments of epidemiology and health services,university of washington,seattle,wa,united states,group health research institute,group health cooperative,seattle,wa, United States, medical genetics research institute,cedars-sinai medical center,los angeles,ca, United States, unit of epidemiology,school of public health,hebrew university-hadassah,jerusalem, Israel, division of aging,department of medicine,brigham and women's hospital,harvard medical school,boston,ma,united states,boston va healthcare system,boston,ma, United States, department of epidemiology and nutrition,harvard school of public health,boston,ma,united states,school of medicine and pharmacology,university of western australia,perth, Australia, cardiovascular health research unit,department of medicine,university of washington,seattle,wa,united states,department of epidemiology,school of public health,university of washington,seattle,wa, United States, department of internal medicine,erasmus mc,rotterdam, Netherlands, department of epidemiology,university of alabama at birmingham,birmingham,al, United States, clinical research branch,national institute on aging,national institutes of health,baltimore,md, United States, institute of molecular medicine,university of texas health science center at houston,houston,tx,united states,division of epidemiology,human genetics,and environmental sciences,university of texas health science center at houston,houston,tx, United States, laboratory medicine and pathology,university of minnesota,minneapolis,mn, United States, department of epidemiology and nutrition,harvard school of public health,boston,ma,united states,division of cardiovascular medicine,brigham and women's hospital,harvard medical school,boston,ma, United States, division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|