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Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations
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نویسنده
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noguchi e. ,sakamoto h. ,hirota t. ,ochiai k. ,imoto y. ,sakashita m. ,kurosaka f. ,akasawa a. ,yoshihara s. ,kanno n. ,yamada y. ,shimojo n. ,kohno y. ,suzuki y. ,kang m.-j. ,kwon j.-w. ,hong s.-j. ,inoue k. ,goto y.-i. ,yamashita f. ,asada t. ,hirose h. ,saito i. ,fujieda s. ,hizawa n. ,sakamoto t. ,masuko h. ,nakamura y. ,nomura i. ,tamari m. ,arinami t. ,yoshida t. ,saito h. ,matsumoto k.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 7
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چکیده
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Asthma is a complex phenotype influenced by genetic and environmental factors. we conducted a genome-wide association study (gwas) with 938 japanese pediatric asthma patients and 2,376 controls. single-nucleotide polymorphisms (snps) showing strong associations (p<1×10 -8) in gwas were further genotyped in an independent japanese samples (818 cases and 1,032 controls) and in korean samples (835 cases and 421 controls). snp rs987870,located between hla-dpa1 and hla-dpb1,was consistently associated with pediatric asthma in 3 independent populations (p combined = 2.3×10 -10,odds ratio [or] = 1.40). hla-dp allele analysis showed that dpa1*0201 and dpb1*0901,which were in strong linkage disequilibrium,were strongly associated with pediatric asthma (dpa1*0201: p = 5.5×10 -10,or = 1.52,and dpb1*0901: p = 2.0×10 -7,or = 1.49). our findings show that genetic variants in the hla-dp locus are associated with the risk of pediatric asthma in asian populations. © 2011 noguchi et al.
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آدرس
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department of medical genetics,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, division of genetics,national cancer center research institute,tokyo, Japan, laboratory of respiratory diseases,riken center for genomic medicine,yokohama, Japan, department of medical genetics,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, department of medical genetics,graduate school of comprehensive human sciences,university of tsukuba,tsukuba,japan,departments of otorhinolaryngology head and neck surgery,faculty of medical science,university of fukui,fukui, Japan, departments of otorhinolaryngology head and neck surgery,faculty of medical science,university of fukui,fukui, Japan, kurosaka pediatrics and allergy clinic,himji, Japan, department of allergy,tokyo metropolitan children's medical center,tokyo, Japan, department of pediatrics,dokkyo medical university,tochigi, Japan, department of pediatrics,dokkyo medical university,tochigi, Japan, department of pediatrics,dokkyo medical university,tochigi, Japan, department of pediatrics,graduate school of medicine,chiba university,chiba, Japan, department of pediatrics,graduate school of medicine,chiba university,chiba, Japan, department of public health,graduate school of medicine,chiba university,chiba, Japan, childhood asthma atopy center,department of pediatrics,asan medical center,university of ulsan college of medicine,seoul, South Korea, childhood asthma atopy center,department of pediatrics,asan medical center,university of ulsan college of medicine,seoul, South Korea, childhood asthma atopy center,department of pediatrics,asan medical center,university of ulsan college of medicine,seoul, South Korea, department of mental retardation and birth defect research,national institute of neuroscience,national center of neurology and psychiatry,tokyo, Japan, department of mental retardation and birth defect research,national institute of neuroscience,national center of neurology and psychiatry,tokyo, Japan, department of mental retardation and birth defect research,national institute of neuroscience,national center of neurology and psychiatry,tokyo,japan,department of psychiatry,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, department of psychiatry,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, health center,keio university,tokyo, Japan, health center,keio university,tokyo, Japan, departments of otorhinolaryngology head and neck surgery,faculty of medical science,university of fukui,fukui, Japan, department of respiratory medicine,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, department of respiratory medicine,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, department of respiratory medicine,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, laboratory of respiratory diseases,riken center for genomic medicine,yokohama, Japan, department of allergy and immunology,national research institute for child health and development,tokyo, Japan, laboratory of respiratory diseases,riken center for genomic medicine,yokohama, Japan, department of medical genetics,graduate school of comprehensive human sciences,university of tsukuba,tsukuba, Japan, division of genetics,national cancer center research institute,tokyo, Japan, department of allergy and immunology,national research institute for child health and development,tokyo, Japan, department of allergy and immunology,national research institute for child health and development,tokyo, Japan
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Authors
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