Safety of concurrent treatment of dogs with fluralaner (Bravecto™) and milbemycin oxime - Praziquantel

Background: fluralaner (bravecto™; merck/msd animal health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. milbemycin oxime and praziquantel are routinely used to control dirofilaria immitis and intestinal worm infections in dogs. the safety of concurrent use of fluralaner and a commercially available milbemycin oxime plus praziquantel combination tablet,in particular with regard to gastrointestinal symptoms,was investigated using oral doses at or above the maximum recommended rates. findings: some minor and transient clinical findings were observed during the study period; however,none of these was considered to be related to concurrent treatment with fluralaner and milbemycin oxime plus praziquantel,or to the use of either product alone. conclusions: concurrent treatment with fluralaner,milbemycin oxime and praziquantel is well tolerated in dogs. © 2014 walther et al.