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Hemozoin knobs in Opisthorchis felineus infected liver
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نویسنده
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pershina a.g. ,saltykova i.v. ,ivanov v.v. ,perina e.a. ,demin a.m. ,shevelev o.b. ,buzueva i.i. ,gutakovskii a.k. ,vtorushin s.v. ,ganebnykh i.n. ,krasnov v.p. ,sazonov a.e. ,ogorodova l.m.
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منبع
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parasites and vectors - 2015 - دوره : 8 - شماره : 1
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چکیده
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Background: hemozoin is the pigment produced by some blood-feeding parasites. it demonstrates high diagnostic and therapeutic potential. in this work the formation of co-called hemozoin knobs - the bile duct ectasia filled up by hemozoin pigment - in opisthorhis felineus infected hamster liver has been observed. methods: the o. felineus infected liver was examined by histological analysis and magnetic resonance imaging (mri). the pigment hemozoin was identified by fourier transform infrared spectroscopy and high resolution electrospray ionization mass spectrometry analysis. hemozoin crystals were characterised by high resolution transmission electron microscopy. results: hemozoin crystals produced by o. felineus have average length 403 nm and the length-to-width ratio equals 2.0. the regurgitation of hemozoin from parasitic fluke during infection leads to formation of bile duct ectasia. the active release of hemozoin from o. felineus during in vitro incubation has also been evidenced. it has been shown that the hemozoin knobs can be detected by magnetic resonance imaging. conclusions: in the paper for the first time the characterisation of hemozoin pigment extracted from liver fluke o. felineus has been conducted. the role of hemozoin in the modification of immune response by opisthorchiasis is assumed. © 2015 pershina et al.
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کلیدواژه
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Bile duct ectasia; Hemozoin; Magnetic resonance imaging (MRI); Opisthorchis felineus; Transmission electron microscopy (TEM); Trematode
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آدرس
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siberian state medical university,2,moskovsky trakt,tomsk,634050,russian federation,national research tomsk polytechnic university,30,lenina ave,tomsk,634050, Russian Federation, siberian state medical university,2,moskovsky trakt,tomsk,634050,russian federation,national research tomsk state university,36,lenina ave,tomsk,634050, Russian Federation, siberian state medical university,2,moskovsky trakt,tomsk,634050, Russian Federation, siberian state medical university,2,moskovsky trakt,tomsk,634050, Russian Federation, postovsky institute of organic synthesis,ub ras,22,s. kovalevskoy st,yekaterinburg,620137, Russian Federation, institute of cytology and genetics,sb ras,10,lavrentyev ave,novosibirsk,630090, Russian Federation, federal state budgetary scientific institution,scientific research institute of physiology and basic medicine,4,timakova st,novosibirsk,630117, Russian Federation, rzhanov institute of semiconductor physics,sb ras,13,lavrentyev ave,novosibirsk,630090, Russian Federation, siberian state medical university,2,moskovsky trakt,tomsk,634050, Russian Federation, postovsky institute of organic synthesis,ub ras,22,s. kovalevskoy st,yekaterinburg,620137, Russian Federation, postovsky institute of organic synthesis,ub ras,22,s. kovalevskoy st,yekaterinburg,620137, Russian Federation, siberian state medical university,2,moskovsky trakt,tomsk,634050, Russian Federation, siberian state medical university,2,moskovsky trakt,tomsk,634050, Russian Federation
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Authors
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