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Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction
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نویسنده
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teixeira t.l. ,cruz l. ,mortara r.a. ,da silva c.v.
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منبع
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parasites and vectors - 2015 - دوره : 8 - شماره : 1
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چکیده
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Background: invasion of host cells by trypanosoma cruzi extracellular amastigotes is host actin polymerization-dependent. however,the role of proteins related to actin dynamics during invasion by amastigotes remains to be investigated. here we describe the role of annexin a2 and arf-6 during extracellular amastigote-mammalian cell interactions. findings: our results showed arf-6 accumulation in the amastigote-containing parasitophorous vacuole containing amastigote forms; demonstrated arf-6 and annexin a2 critical impact over parasite cell invasion and revealed the effect of annexin a2 expression on intracellular parasite multiplication. conclusion: arf-6 and annexin a2 are involved in invasion of mammalian cells by t. cruzi amastigotes. © 2015 teixeira et al.
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کلیدواژه
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Actin cytoskeleton; Annexin A2; ARF-6; Cell invasion; Extracellular amastigotes; Trypanosoma cruzi
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آدرس
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instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia, Brazil, universidade federal de são paulo,são paulo, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,brazil,laboratório de tripanosomatídeos,disciplina de imunologia,instituto de ciências biomédicas,universidade federal de uberlândia,rua piauí,bloco 2b,campus umuarama,uberlândia,mg 38400-902, Brazil
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Authors
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