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Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease
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نویسنده
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sun s. ,wang x. ,wu x. ,zhao y. ,wang f. ,liu x. ,song y. ,wu z. ,liu m.
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منبع
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parasites and vectors - 2011 - دوره : 4 - شماره : 1
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چکیده
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Helminth infection may modulate the expression of toll like receptors (tlr) in dendritic cells (dcs) and modify the responsiveness of dcs to tlr ligands. this may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (ibd). epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. fine control of inflammation in the tlr pathway is highly desirable for effective host defense. thus,the use of antagonists of tlr-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of ibd. © 2011 sun et al; licensee biomed central ltd.
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کلیدواژه
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Helminth; Inflammatory Bowel Disease; Toll Like Receptors
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آدرس
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ministry of education,institute of zoonosis,jilin university,changchun 130062,china,animal science and technology college,inner mongolia university for nationalities,028000 tongliao, China, ministry of education,institute of zoonosis,jilin university,changchun 130062, China, ministry of education,institute of zoonosis,jilin university,changchun 130062, China, ministry of education,institute of zoonosis,jilin university,changchun 130062, China, ministry of education,institute of zoonosis,jilin university,changchun 130062, China, ministry of education,institute of zoonosis,jilin university,changchun 130062, China, ministry of education,institute of zoonosis,jilin university,changchun 130062, China, department of parasitology,gifu university,graduate school of medicine,yanagido 1-1,gifu 501-1194, Japan, ministry of education,institute of zoonosis,jilin university,changchun 130062, China
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Authors
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