Efficacy of slow-release collar formulations of imidacloprid/flumethrin and deltamethrin and of spot-on formulations of fipronil/(s) - Methoprene,dinotefuran/pyriproxyfen/permethrin and (s) -methoprene/amitraz/fipronil against Rhipicephalus sanguineus and Ctenocephalides felis felis on dogs

Background: two studies evaluating the efficacy of an imidacloprid/ flumethrin collar (seresto®,bayer animal health,ivp),a deltamethrin collar (scalibor®,msd,cp1),a fipronil/(s)-methoprene spot-on (frontline combo®,merial,cp2),a dinotefuran/pyriproxyfen/permethrin spot-on (vectra 3d®,ceva,cp3) and an amitraz/fipronil/(s)-methoprene spot-on (certifect®,merial,cp4/cp5) against repeated infestations with rhipicephalus sanguineus and ctenocephalides felis felis on dogs were conducted over periods of 226 days and 71 days respectively. methods: the first study comprised 4 groups of treated dogs and one untreated control group,and the second 3 groups of treated dogs and one control group. each group consisted of 8 dogs. all dogs were infested with ticks and fleas at regular intervals. ticks were counted 6 h,18 h or 48 h after infestations and fleas 24 h after infestations. efficacies of the treatments were calculated by comparison with the untreated control groups using standard descriptive statistics. results: the protective 48 h tick efficacy was 97.8% to 100% for the ivp (226 days),69.3% to 97.4% for cp1 (170 days),99.6% to 43.4% for cp2 (35 days) and 98% to 61.4% for cp3 (35 days). the protective 18 h tick efficacy was 98% to 99.6% for the ivp (71 days),100% to 86.5% for cp4 (29 days),100% to 72.8% for cp4 after re-treatment (35 days) and 98.8% to 54.3% for cp5 (35 days). the protective 6 h tick efficacy was 85.6% at day 7 and 90.1% to 97.1% from day 14 onwards for the ivp (70 days),92.3% to 70.7% for cp4 (35 days),97.5% to 65.2% for cp4 after re-treatment (35 days) and 95.1% to 51.8% for cp5 (35 days). the protective 24 h flea efficacy was 99.5/90.9% to 100% for the ivp (71/226 days),66.7% to 83% for cp1 (170 days),100% to 88.5% for cp2 (35 days),100% to 73.3% for cp3 (35 days),100% to 98.7% for cp4 (35 days),100% to 87.5% for cp4 after re-treatment (35 days) and 100% to 79.5% for cp5 (35 days). © 2012 horak et al.; licensee biomed central ltd.