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Synthesis and anti-angiogenic effect of conjugates between serum albumin and non-steroidal anti-inflammatory drugs
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نویسنده
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kjær b. ,struve c. ,friis t. ,engel a.-m. ,beyer n.h. ,højrup p. ,houen g.
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منبع
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protein and peptide letters - 2010 - دوره : 17 - شماره : 1 - صفحه:121 -130
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چکیده
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Non-steroidal anti-inflammatory drugs (nsaids) inhibit tumor growth and angiogenesis. covalent linkage of naproxen to human serum albumin (hsa) has been shown to target it efficiently to the liver and this may potentially be exploited for liver-selective inhibition of angiogenesis. with the aim of investigating the anti-angiogenic efficiency of nsaid-hsa conjugates in vitro,three nsaids,aspirin,ibuprofen,and naproxen were conjugated to hsa using different concentrations of their n-hydroxysuccinimide esters. conjugation ratios from 10 to 50 were achieved and the conjugates retained a growth inhibitory effect on endothelial cells at or above the level of the non-conjugated nsaids in an in vitro angiogenesis assay. © 2010 bentham science publishers ltd.
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کلیدواژه
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Angiogenesis; Conjugation; HSA; HUVEC; NSAID
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آدرس
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department of clinical biochemistry and immunology,statens serum institut,artillerivej 5, Denmark, department of clinical biochemistry and immunology,statens serum institut,artillerivej 5, Denmark, department of clinical biochemistry and immunology,statens serum institut,artillerivej 5, Denmark, bartholin institute,division of immunology and cancer,rigshospitalet,blegdamsvej 9, Denmark, department of autoimmunology,statens serum institut,artillerivej 5, Denmark, department of biochemistry and molecular biology,university of southern denmark,campusvej 55, Denmark, department of clinical biochemistry and immunology,statens serum institut,artillerivej 5,dk-2300 copenhagen s,denmark,department of autoimmunology,statens serum institut,artillerivej 5, Denmark
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Authors
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