Molecular modeling of human BAD,a pro-apoptotic Bcl-2 family member,integrating glycolysis and apoptosis
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نویسنده
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yang j.
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منبع
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protein and peptide letters - 2010 - دوره : 17 - شماره : 2 - صفحه:206 -220
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چکیده
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Comparison between the bad complexes indicated that bad all docks a hydrophobic surface of pkac regardless of its phosphorylation. pkac may prevent bcl-xl from rebinding to bad by phosphorylating human bad at ser118; whereas human bad is phosphorylated on ser75 in a bad-bcl-xl complex,resulting in the dissociation of bad. © 2010 bentham science publishers ltd.
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کلیدواژه
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Computational modeling; Protein-protein interaction; Sequence alignment
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آدرس
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department of biochemistry and molecular biology,college of life sciences,nanjing university, China
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