Immunization with peptide-protein conjugates: Impact on benchmarking B-cell epitope prediction for vaccine design
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نویسنده
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caaoili s.e.c.
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منبع
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protein and peptide letters - 2010 - دوره : 17 - شماره : 3 - صفحه:386 -398
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چکیده
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Benchmarking b-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates,as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes. © 2010 bentham science publishers ltd.
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کلیدواژه
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Antipeptide antibody; B-cell epitope prediction; Peptide-based vaccine; Peptide-protein cross-reactivity; Peptideprotein conjugation; Structural energetics
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آدرس
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department of biochemistry and molecular biology,college of medicine, Philippines
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