|
|
|
|
Interactions of Ginkgolides A and B with a recombinant human prion protein
|
|
|
|
|
|
|
|
نویسنده
|
georgieva d. ,redecke l. ,von bergen m. ,genov n. ,betzel c.
|
|
منبع
|
protein and peptide letters - 2010 - دوره : 17 - شماره : 3 - صفحه:399 -404
|
|
چکیده
|
In the presence of ginkgolides a and b a recombinant human prion protein (90-231) is more susceptible to proteolysis,which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. probably,ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure. © 2010 bentham science publishers ltd.
|
|
کلیدواژه
|
Ginkgolide; Prion protein; Protein misfolding; Structural transformation; Three-dimensional structure
|
|
آدرس
|
institute of biochemistry and molecular biology,laboratory of structural biology of infection and inflammation,c/o desy,building 22a,notkesttasse 85, Germany, institute of biochemistry and molecular biology,laboratory of structural biology of infection and inflammation,c/o desy,building 22a,notkesttasse 85, Germany, helmholtz-centre for environmental research-ufz,department of proteomics,permoser strasse 15, Germany, institute of organic chemistry,bulgarian academy of sciences,'acad. g. bonchev'-str. bl. 9, Bulgaria, institute of biochemistry and molecular biology,laboratory of structural biology of infection and inflammation,c/o desy,building 22a,notkesttasse 85, Germany
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|