|
|
|
|
Codon usage biases in Alzheimer's disease and other neurodegenerative diseases
|
|
|
|
|
|
|
|
نویسنده
|
yang j. ,zhu t.-y. ,jiang z.-x. ,chen c. ,wang y.-l. ,zhang s. ,jiang x.-f. ,wang t.-t. ,wang l. ,xia w.-h. ,li l. ,chen j.-j. ,wang j.-y. ,wang w.-w. ,zheng w.-j.
|
|
منبع
|
protein and peptide letters - 2010 - دوره : 17 - شماره : 5 - صفحه:630 -645
|
|
چکیده
|
Establishing codon usage biases are crucial for understanding the etiology of central nervous system neurode-generative diseases (cnsndd) especially alzheimer's disease (ad) as well as genetic factors. g and c ending codons are strongly biased in the coding sequences of these proteins as a result of genomic gc composition constraints. on the other hand,codons that identified as translationally optimal in the major trend all end in c or g,suggesting translational selection should also be taken into consideration additional to compositional constraints. furthermore,this investigation reveals that three common codons,cgc (arg),agc (ser),and ggc (gly),are also critical in affecting codon usage bias. they not only can offer an insight into the codon usage bias of ad and its mechanism,but also may help in the possible cures for these diseases. © 2010 bentham science publishers ltd.
|
|
کلیدواژه
|
Codon usage; Compositional constraints; Correspondence analysis; Translational selection
|
|
آدرس
|
department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China, department of biochemistry,nanjing university, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|