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Synthetic strategies to a backbone-side chain cyclic SHP-1 N-SH2 ligand containing N-functionalized alkyl phosphotyrosine
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نویسنده
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teichmann k. ,niksch t. ,wieligmann k. ,zacharias m. ,imhof d.
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منبع
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protein and peptide letters - 2010 - دوره : 17 - شماره : 7 - صفحه:809 -816
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چکیده
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The cyclic peptide eglncψ[con((ch2)3nh)pynlee(nhch2co)]l-nh2 (1) was designed and synthesized according to a native interaction partner of tyrosine phosphatase shp-1. we introduced n-aminopropyl-phosphotyrosine to enable backbone-side chain cyclization with a glutamic acid derivative as counterpart for cyclization. different approaches have been compared to find a strategy for the generation of backbone and backbone-side chain cyclic phosphopeptides. © 2010 bentham science publishers ltd.
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کلیدواژه
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Backbone cyclization; Ligand; N-functionalized alkyl phosphotyrosine; Protein tyrosine phosphatase; SH2 domain; SHP-1
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آدرس
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center for molecular biomedicine,department of biochemistry,peptide chemistry group,friedrich-schiller-university jena,hans-knöll-straße 2, Germany, institute of inorganic and analytical chemistry,friedrich-schiller-university jena,august-bebel-str. 2, Germany, max planck research unit for enzymology of protein folding,weinbergweg 22, Germany, physik department t38,technische universität münchen,james-franck-str. 1, Germany, center for molecular biomedicine,department of biochemistry,peptide chemistry group,friedrich-schiller-university jena,hans-knöll-straße 2, Germany
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Authors
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