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Synthesis of n-glycopeptides applying glycoamino acid building blocks with a combined fmoc/boc strategy
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نویسنده
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rákosi k. ,szolomájer-csikós o. ,kalmár l. ,szurmai z. ,kerékgyártó j. ,tóth g.k.
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منبع
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protein and peptide letters - 2011 - دوره : 18 - شماره : 7 - صفحه:679 -683
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چکیده
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Mono-,di- and trisaccharide representing the reducing terminal of the core structure of n-glycans were incorporated into leu-lys-asn-gly-gly-pro hexapeptide that is a partial structure of the trp-cage mini-protein by linear assembly. these studies provide evidence that the used combination of fmoc and boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield. © 2011 bentham science publishers ltd.
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کلیدواژه
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Boc deprotection; Carbohydrates; N-glycopeptides; Solid-phase synthesis; Tin(IV) chloride
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آدرس
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department of medical chemistry,faculty of general medicine,university of szeged,dóm tér 8, Hungary, department of medical chemistry,faculty of general medicine,university of szeged,dóm tér 8, Hungary, department of medical chemistry,faculty of general medicine,university of szeged,dóm tér 8,6720 szeged,hungary,department of botany,bio-organic laboratory,university of debrecen,egyetem tér 1, Hungary, department of applied ecology,bio-organic laboratory,university of debrecen,egyetem tér 1, Hungary, department of botany,bio-organic laboratory,university of debrecen,egyetem tér 1, Hungary, department of medical chemistry,faculty of general medicine,university of szeged,dóm tér 8, Hungary
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Authors
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