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Synthesis of oligopeptides through O-acyl isopeptide method
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نویسنده
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lalithamba h.s. ,hemantha h.p. ,sureshbabu v.v.
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منبع
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protein and peptide letters - 2011 - دوره : 18 - شماره : 8 - صفحه:848 -857
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چکیده
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The o-acyl isopeptide method has recently gained attention as an efficient protocol for the synthesis of 'difficult sequence' peptides. herein,synthesis of three oligopeptides of different length,a pentapeptide gly-leu-leu-ser-val,a heptapeptide fragment 285-291 of transmembrane (m7-24-t40) ala-val-leu-ser-leu-pro-leu and a decapeptide,gly-leu-leu-ser-val-leu-gly-ser- val-ala were demonstrated in solution phase by employing o-acyl isopeptide method. the peptides were established through an efficient ph triggered intramolecular o→n acyl migration under physiological conditions. the reactions were clean and complete in appreciable length of time. © 2011 bentham science publishers ltd.
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کلیدواژه
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'Click' peptide; O→N intramolecular acyl migration; O-acyl isopeptide
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آدرس
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peptide research laboratory,department of studies in chemistry,bangalore university,dr. b.r. ambedkar veedhi, India, peptide research laboratory,department of studies in chemistry,bangalore university,dr. b.r. ambedkar veedhi, India, peptide research laboratory,department of studies in chemistry,bangalore university,dr. b.r. ambedkar veedhi, India
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Authors
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