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Improved Fmoc synthesis of Bradykinin
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نویسنده
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stephenson r.j. ,plieger p.g. ,harding d.r.k.
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منبع
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protein and peptide letters - 2011 - دوره : 18 - شماره : 9 - صفحه:952 -955
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چکیده
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Two arginine side-chain protecting groups,n g-4-methoxy-2,3,6- trimethylbenzensulfonyl group (mtr) and n g-2,2,5,7,8- pentamethylchroman-6-sulfonyl (pmc),have been investigated at both the arg 1 and/or arg 9 position of the bioactive peptide,bradykinin using fluorenylmethyloxycarbonyl (fmoc) solid phase peptide synthesis. a more efficient synthesis of the peptide has been found when a combination of arg(mtr) is present at position 1 and arg(pmc) is present at position 9 giving a cleaved pure yield of 52%. © 2011 bentham science publishers ltd.
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کلیدواژه
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Bradykinin; Drug delivery; Fmoc solid phase peptide synthesis; RP-HPLC
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آدرس
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institute of fundamental sciences,massey university,turitea campus,private bag 11-222, New Zealand, institute of fundamental sciences,massey university,turitea campus,private bag 11-222, New Zealand, institute of fundamental sciences,massey university,turitea campus,private bag 11-222, New Zealand
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Authors
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