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SCYPPred: A web-based predictor of SNPs for human cytochrome P450
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نویسنده
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li l. ,wei d.-q. ,wang j.-f. ,chou k.-c.
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منبع
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protein and peptide letters - 2012 - دوره : 19 - شماره : 1 - صفحه:57 -61
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چکیده
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Human cytochrome p450(cyp 450) enzymes mediate over 60% of the phase i-dependent metabolism of clinical drugs. they are also known for the polymorphism functions that have significant impacts on the enzyme activities. in this study,a web-server called scyppred was developed for predicting human cytochrome p450 snps (single nucleotide polymorphisms) based on the svm flanking sequence method; scyppred can rapidly yield the desired results by using the amino acid sequences information alone. the web-server is accessible to the public at http://snppred.sjtu.edu.cn. hopefully scyppred could be a useful bioinformatics tool for elucidating the mutation probability of a specific cyp450 enzyme. © 2012 bentham science publishers.
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کلیدواژه
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Cytochrome P450; Mutation Probability; SNPs; SVM
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آدرس
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state key laboratory of microbial metabolism,college of life sciences and biotechnology,shanghai jiao tong university,800 dongchuan road,shanghai, China, state key laboratory of microbial metabolism,college of life sciences and biotechnology,shanghai jiao tong university,800 dongchuan road,shanghai, China, key laboratory of systems biomedicine ministry of education,shanghai centre for systems biomedicine,shanghai jiaotong university,800 dongchuan road,shanghai 200240,china,shanghai centre for bioinformation technology,100 qinzhou road,shanghai 200235,china,gordon life science institute,13784 torrey del mar drive,san diego, United States, gordon life science institute,13784 torrey del mar drive,san diego, United States
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Authors
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