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Selection of reprogramming factors of induced pluripotent stem cells based on the protein interaction network and functional profiles
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نویسنده
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huang t. ,cai y.-d. ,chen l. ,hu l.-l. ,kong x.-y. ,li y.-x. ,chou k.-c.
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منبع
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protein and peptide letters - 2012 - دوره : 19 - شماره : 1 - صفحه:113 -119
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چکیده
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Induced pluripotent stem cells have displayed great potential in disease investigation and drug development applications. however,selection of reprogramming factors in each cell type or disease state is both expensive and time consuming. to deal with this kind of situation,a fast computational framework was developed by optimize the reprogramming factors via the protein interaction network and gene functional profiles. it can be used to select reprogramming factors from millions of possibilities. it is anticipated that the novel approach will become a very useful tool for both basic research and drug development. © 2012 bentham science publishers.
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کلیدواژه
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Disease investigation; Gene functional profiles; Protein interaction network; Reprogramming factors; Stem cells
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آدرس
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key laboratory of systems biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china,shanghai center for bioinformation technology, China, institute of systems biology,shanghai university,shanghai 200444,china,centre for computational systems biology,fudan university,shanghai 200433,china,gordon life science institute,san diego, United States, shanghai key laboratory of trustworthy computing,east china normal university,shanghai, China, institute of systems biology,shanghai university, China, key laboratory of stem cell biology,institute of health sciences,shanghai jiao tong university school of medicine,shanghai 200025,china,state key laboratory of medical genomics,ruijin hospital,shanghai jiaotong university, China, key laboratory of systems biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china,shanghai center for bioinformation technology, China, gordon life science institute,san diego, United States
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Authors
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